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dc.contributor.authorMononen Mika
dc.contributor.authorTanska Petri
dc.contributor.authorIsaksson Hanna
dc.contributor.authorKorhonen Rami
dc.date.accessioned2018-01-10T11:21:58Z
dc.date.available2018-01-10T11:21:58Z
dc.date.issued2017
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/5147
dc.description.abstractOsteoarthritis is a harmful joint disease but prediction of disease progression is problematic. Currently, there is only one modeling framework which can be applied to predict the progression of knee osteoarthritis but it only considers degenerative changes in the collagen fibril network. Here, we have developed the framework further by considering all of the major tissue changes (proteoglycan content, fluid flow, and collagen fibril network) occurring in osteoarthritis. While excessive levels of tissue stresses controlled degeneration of the collagen fibril network, excessive levels of tissue strains controlled the decrease in proteoglycan content and the increase in permeability. We created four knee joint models with increasing degrees of complexity based on the depth-wise composition. Models were tested for normal and abnormal, physiologically relevant, loading conditions in the knee. Finally, the predicted depth-wise compositional changes from each model were compared against experimentally observed compositional changes in vitro. The model incorporating the typical depth-wise composition of cartilage produced the best match with experimental observations. Consistent with earlier in vitro experiments, this model simulated the greatest proteoglycan depletion in the superficial and middle zones, while the collagen fibril degeneration was located mostly in the superficial zone. The presented algorithm can be used for predicting simultaneous collagen degeneration and proteoglycan loss during the development of knee osteoarthritis.en
dc.publisherWiley-Blackwellen
dc.relation.ispartofseriesJOURNAL OF ORTHOPAEDIC RESEARCHen
dc.relation.urihttp://dx.doi.org/10.1002/jor.23811en
dc.rightsAll rights reserveden
dc.subjectknee jointen
dc.subjectarticular cartilageen
dc.subjectosteoarthritisen
dc.subjectfinite element analysisen
dc.subjectdegenerationen
dc.titleNew Algorithm for Simulation of Proteoglycan Loss and Collagen Degeneration in the Knee Joint: Data from the Osteoarthritis Initiativeen
dc.description.versionfinal draften
dc.contributor.departmentDepartment of Applied Physics, activitiesen
uef.solecris.id50992082en
dc.type.publicationinfo:eu-repo/semantics/articleen
dc.rights.accessrights© Orthopaedic Research Societyen
dc.relation.projectidinfo:eu-repo/grantAgreement/EC/FP7-IDEAS-ERC/281180/EU/Evaluation of Osteoarthritis Progression in a Patient-Specific Manner using Magnetic Resonance Imaging and Computational Modeling/OAPROGRESSen
dc.relation.doi10.1002/jor.23811en
dc.description.reviewstatuspeerRevieweden
dc.relation.issn0736-0266en
dc.relation.volume[First published 19 Dec 2017]en
dc.rights.accesslevelopenAccessen
dc.type.okmA1en
dc.type.versioninfo:eu-repo/semantics/acceptedVersionen
uef.solecris.openaccessEi


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