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dc.contributor.authorKorpelainen Sini
dc.contributor.authorIntke Carina
dc.contributor.authorHämäläinen Sari
dc.contributor.authorJantunen Esa
dc.contributor.authorJuutilainen Auni
dc.contributor.authorPulkki Kari
dc.date.accessioned2018-01-10T13:16:40Z
dc.date.available2018-01-10T13:16:40Z
dc.date.issued2017
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/5150
dc.description.abstractObjective. Elevated levels of a cell surface glycoprotein, soluble cluster of differentiation 14 (sCD14), have been observed in patients with sepsis. Only scarce data are available on sCD14 in hematological patients with chemotherapy-induced febrile neutropenia. The study aim was to investigate sCD14 as an early biomarker in febrile neutropenia after intensive chemotherapy to detect a rapidly deteriorating clinical course early enough to avoid serious infectious complications. Patients and Methods. This prospective study included 87 adult hematological patients at the start of febrile neutropenia after intensive chemotherapy for acute myeloid leukemia or after autologous stem cell transplantation. The study endpoints were septic shock, severe sepsis, and positive blood culture findings. sCD14 was analyzed from day 0 to day 2, and its prognostic capacity was compared to that of C-reactive protein and procalcitonin. Results. Plasma level of sCD14 predicted the development of septic shock on day 1 () and day 2 but not the development of severe sepsis or blood culture positivity in hematological patients with chemotherapy-induced febrile neutropenia. Conclusions. Soluble CD14 did not predict an overall complicated course at the early stages of febrile neutropenia. However, it was helpful in predicting the progression of the clinical course of neutropenic fever to septic shock.en
dc.language.isoENen
dc.publisherHindawi Limiteden
dc.relation.ispartofseriesDISEASE MARKERSen
dc.relation.urihttp://dx.doi.org/10.1155/2017/9805609en
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/en
dc.titleSoluble CD14 as a Diagnostic and Prognostic Biomarker in Hematological Patients with Febrile Neutropeniaen
dc.description.versionpublished versionen
dc.contributor.departmentSchool of Medicine / Clinical Medicineen
uef.solecris.id49391169en
dc.type.publicationinfo:eu-repo/semantics/articleen
dc.rights.accessrights© Authorsen
dc.relation.doi10.1155/2017/9805609en
dc.description.reviewstatuspeerRevieweden
dc.relation.articlenumber9805609en
dc.relation.issn0278-0240en
dc.relation.volume2017en
dc.rights.accesslevelopenAccessen
dc.type.okmA1en
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
uef.solecris.openaccessOpen access -julkaisukanavassa ilmestynyt julkaisu


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