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Synthesis of a Biologically Important Adenosine Triphosphate Analogue, ApppD

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Date
2017
Author(s)
Turhanen Petri
Unique identifier
10.1021/acsomega.7b00531
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Citation
Turhanen Petri. (2017). Synthesis of a Biologically Important Adenosine Triphosphate Analogue, ApppD.  ACS Omega, 2 (6) , 2835-2838. 10.1021/acsomega.7b00531.
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© American Chemical Society
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Abstract

The chemical synthesis of a adenosine triphosphate analogue, 1-adenosin-5′-yl 3-(3-methylbut-2-enyl) triphosphoric acid diester (ApppD), is described. ApppD is known to be an active metabolite of the mevalonate pathway in the human body like its structural isomer isopentenyl ester of ATP (ApppI). Very recently, ApppI has been found to possess novel function(s); now it will also be possible to examine the effects of ApppD more precisely because it can be synthesized in reasonable amounts. 1-Adenosin-5′-yl 3-(3-methylbut-2-enyl) diphosphoric acid diester (AppD; a adenosine diphosphate analogue) was also isolated from the synthesis mixture. Both ApppD and AppD were characterized by 1H, 13C, 31P NMR and mass spectrometry methods.

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https://erepo.uef.fi/handle/123456789/5152
Link to the original item
http://dx.doi.org/10.1021/acsomega.7b00531
Publisher
American Chemical Society (ACS)
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  • Luonnontieteiden ja metsätieteiden tiedekunta [1127]
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