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dc.contributor.authorLaurén P
dc.contributor.authorSomersalo P
dc.contributor.authorPitkänen I
dc.contributor.authorLou YR
dc.contributor.authorUrtti A
dc.contributor.authorPartanen J
dc.contributor.authorSeppälä J
dc.contributor.authorMadetoja M
dc.contributor.authorLaaksonen T
dc.contributor.authorMäkitie A
dc.contributor.authorYliperttula M
dc.date.accessioned2018-01-12T11:24:37Z
dc.date.available2018-01-12T11:24:37Z
dc.date.issued2017
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/5168
dc.description.abstractHydrogel nanomaterials, especially those that are of non-human and non-animal origins, have great potential in biomedical and pharmaceutical sciences due to their versatility and inherent soft-tissue like properties. With the ability to simulate native tissue function, hydrogels are potentially well suited for cellular therapy applications. In this study, we have fabricated nanofibrillar cellulose-alginate (NFCA) suture coatings as biomedical devices to help overcome some of the limitations related to cellular therapy, such as low cell survivability and distribution out of target tissue. The addition of sodium alginate 8% (w/v) increased the NFCA hydrogel viscosity, storage and loss moduli by slightly under one order of magnitude, thus contributing significantly to coating strength. Confocal microscopy showed nearly 100% cell viability throughout the 2-week incubation period within and on the surface of the coating. Additionally, typical morphologies in the dual cell culture of spheroid forming HepG2 and monolayer type SK-HEP-1 were observed. Twelve out of 14 NFCA coated surgical sutures remained intact during the suturing operation with various mice and rat tissue; however, partial peeling off was observed in 2 of the coated sutures. We conclude that NFCA suture coatings could perform as cell-carrier systems for cellular based therapy and post-surgical treatment.en
dc.language.isoENen
dc.publisherPublic Library of Science (PLoS)en
dc.relation.ispartofseriesPLOS ONEen
dc.relation.urihttp://dx.doi.org/10.1371/journal.pone.0183487en
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/en
dc.titleNanofibrillar cellulose-alginate hydrogel coated surgical sutures as cell-carrier systemsen
dc.description.versionpublished versionen
dc.contributor.departmentSchool of Pharmacy, Activitiesen
uef.solecris.id49391671en
dc.type.publicationinfo:eu-repo/semantics/articleen
dc.rights.accessrights© Authorsen
dc.relation.doi10.1371/journal.pone.0183487en
dc.description.reviewstatuspeerRevieweden
dc.relation.articlenumbere0183487en
dc.relation.issn1932-6203en
dc.relation.issue8en
dc.relation.volume12en
dc.rights.accesslevelopenAccessen
dc.type.okmA1en
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
uef.solecris.openaccessOpen access -julkaisukanavassa ilmestynyt julkaisu


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