Hippocampal Sclerosis and Epilepsy in Elderly Population

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Date
2017
Author
Rauramaa Tuomas
Solomon Alina
Pikkarainen Maria
Kälviäinen Reetta
Alafuzoff Irina
Unique identifier
10.4172/2161-0460.1000384
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Citation
Rauramaa Tuomas. Solomon Alina. Pikkarainen Maria. Kälviäinen Reetta. Alafuzoff Irina. (2017). Hippocampal Sclerosis and Epilepsy in Elderly Population.  Journal of Alzheimers Disease & Parkinsonism, 7 (5) , 384. 10.4172/2161-0460.1000384.
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CC BY http://creativecommons.org/licenses/by/4.0/
Abstract

Objective: In temporal lobe epilepsy, hippocampal sclerosis (HS) and Alzheimer’s disease (AD) pathological alterations in the hippocampus are frequently observed. Methods: We assessed the clinicopathological characteristics of 30 aged subjects with HS originating from a large unselected autopsy cohort including 1,388 individuals. Results: Overall, in 22 subjects AD related pathology and in 17 subjects TDP43 pathology, from mild, moderate to severe was seen. Five subjects out of 30 (17%) with HS had epilepsy. Conclusion: A higher percentage compared to the reported prevalence of epilepsy in 0.6 percent of the adult population was observed, but more post mortem studies are urgently needed to investigate the pathological substrate for epilepsy in AD.

Subjects
Hippocampus   Postmortem   Hippocampal sclerosis   Epilepsy   Alzheimer   
URI
https://erepo.uef.fi/handle/123456789/5745
Link to the original item
http://dx.doi.org/10.4172/2161-0460.1000384
Publisher
OMICS Publishing Group
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