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dc.contributor.authorRauramaa Tuomas
dc.contributor.authorSolomon Alina
dc.contributor.authorPikkarainen Maria
dc.contributor.authorKälviäinen Reetta
dc.contributor.authorAlafuzoff Irina
dc.date.accessioned2018-01-29T08:48:31Z
dc.date.available2018-01-29T08:48:31Z
dc.date.issued2017
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/5745
dc.description.abstractObjective: In temporal lobe epilepsy, hippocampal sclerosis (HS) and Alzheimer’s disease (AD) pathological alterations in the hippocampus are frequently observed. Methods: We assessed the clinicopathological characteristics of 30 aged subjects with HS originating from a large unselected autopsy cohort including 1,388 individuals. Results: Overall, in 22 subjects AD related pathology and in 17 subjects TDP43 pathology, from mild, moderate to severe was seen. Five subjects out of 30 (17%) with HS had epilepsy. Conclusion: A higher percentage compared to the reported prevalence of epilepsy in 0.6 percent of the adult population was observed, but more post mortem studies are urgently needed to investigate the pathological substrate for epilepsy in AD.en
dc.language.isoENen
dc.publisherOMICS Publishing Groupen
dc.relation.ispartofseriesJournal of Alzheimers Disease & Parkinsonismen
dc.relation.urihttp://dx.doi.org/10.4172/2161-0460.1000384en
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/en
dc.subjectHippocampusen
dc.subjectPostmortemen
dc.subjectHippocampal sclerosisen
dc.subjectEpilepsyen
dc.subjectAlzheimeren
dc.titleHippocampal Sclerosis and Epilepsy in Elderly Populationen
dc.description.versionpublished versionen
dc.contributor.departmentSchool of Medicine / Clinical Medicineen
uef.solecris.id50711032en
dc.type.publicationinfo:eu-repo/semantics/articleen
dc.rights.accessrights© Authorsen
dc.relation.doi10.4172/2161-0460.1000384en
dc.description.reviewstatuspeerRevieweden
dc.relation.articlenumber384en
dc.relation.issn2161-0460en
dc.relation.issue5en
dc.relation.volume7en
dc.rights.accesslevelopenAccessen
dc.type.okmA1en
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
uef.solecris.openaccessOpen access -julkaisukanavassa ilmestynyt julkaisu


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