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No Evidence of a Common DNA Variant Profile Specific to World Class Endurance Athletes

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Rinnakkaistallenteen versio
published version
Päivämäärä
2016
Tekijä
Eynon N
Filipenko ML
Garton FC
Generozov EV
Govorun VM
Houweling PJ
Kawahara T
Kostryukova ES
Kulemin NA
Larin AK
Maciejewska-Karlowska A et al. (incl. Rauramaa R)
Yksilöllinen tunniste
10.1371/journal.pone.0147330
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Viittaus
Eynon N. Filipenko ML. Garton FC. Generozov EV. Govorun VM. Houweling PJ. Kawahara T. Kostryukova ES. Kulemin NA. Larin AK. Maciejewska-Karlowska A et al. (incl. Rauramaa R). (2016). No Evidence of a Common DNA Variant Profile Specific to World Class Endurance Athletes.  PLOS ONE, 11 (1) ,  e0147330. 10.1371/journal.pone.0147330.
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© Authors
Lisensointimalli
CC BY http://creativecommons.org/licenses/by/4.0/
Tiivistelmä

There are strong genetic components to cardiorespiratory fitness and its response to exercise training. It would be useful to understand the differences in the genomic profile of highly trained endurance athletes of world class caliber and sedentary controls. An international consortium (GAMES) was established in order to compare elite endurance athletes and ethnicity-matched controls in a case-control study design. Genome-wide association studies were undertaken on two cohorts of elite endurance athletes and controls (GENATHLETE and Japanese endurance runners), from which a panel of 45 promising markers was identified. These markers were tested for replication in seven additional cohorts of endurance athletes and controls: from Australia, Ethiopia, Japan, Kenya, Poland, Russia and Spain. The study is based on a total of 1520 endurance athletes (835 who took part in endurance events in World Championships and/or Olympic Games) and 2760 controls. We hypothesized that world-class athletes are likely to be characterized by an even higher concentration of endurance performance alleles and we performed separate analyses on this subsample. The meta-analysis of all available studies revealed one statistically significant marker (rs558129 at GALNTL6 locus, p = 0.0002), even after correcting for multiple testing. As shown by the low heterogeneity index (I2 = 0), all eight cohorts showed the same direction of association with rs558129, even though p-values varied across the individual studies. In summary, this study did not identify a panel of genomic variants common to these elite endurance athlete groups. Since GAMES was underpowered to identify alleles with small effect sizes, some of the suggestive leads identified should be explored in expanded comparisons of world-class endurance athletes and sedentary controls and in tightly controlled exercise training studies. Such studies have the potential to illuminate the biology not only of world class endurance performance but also of compromised cardiac functions and cardiometabolic diseases.

Avainsanat
Meta-analysis   Sports   Genome-wide association studies   Gene mapping   Genetic loci   Molecular genetics   Human performance   Physical fitness   
URI
https://erepo.uef.fi/handle/123456789/5779
Linkki alkuperäiseen julkaisuun
http://dx.doi.org/10.1371/journal.pone.0147330
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Public Library of Science (PLoS)
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  • Terveystieteiden tiedekunta
University of Eastern Finland
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University of Eastern Finland
OpenAccess
eRepo
erepo@uef.fi
Lähetä palautetta
OpenUEF
Palvelun tarjoaa
Itä-Suomen yliopiston kirjasto
Library web pages
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