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dc.contributor.authorEynon N
dc.contributor.authorFilipenko ML
dc.contributor.authorGarton FC
dc.contributor.authorGenerozov EV
dc.contributor.authorGovorun VM
dc.contributor.authorHouweling PJ
dc.contributor.authorKawahara T
dc.contributor.authorKostryukova ES
dc.contributor.authorKulemin NA
dc.contributor.authorLarin AK
dc.contributor.authorMaciejewska-Karlowska A et al. (incl. Rauramaa R)
dc.contributor.editor
dc.date.accessioned2018-01-31T06:08:00Z
dc.date.available2018-01-31T06:08:00Z
dc.date.issued2016
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/5779
dc.description.abstractThere are strong genetic components to cardiorespiratory fitness and its response to exercise training. It would be useful to understand the differences in the genomic profile of highly trained endurance athletes of world class caliber and sedentary controls. An international consortium (GAMES) was established in order to compare elite endurance athletes and ethnicity-matched controls in a case-control study design. Genome-wide association studies were undertaken on two cohorts of elite endurance athletes and controls (GENATHLETE and Japanese endurance runners), from which a panel of 45 promising markers was identified. These markers were tested for replication in seven additional cohorts of endurance athletes and controls: from Australia, Ethiopia, Japan, Kenya, Poland, Russia and Spain. The study is based on a total of 1520 endurance athletes (835 who took part in endurance events in World Championships and/or Olympic Games) and 2760 controls. We hypothesized that world-class athletes are likely to be characterized by an even higher concentration of endurance performance alleles and we performed separate analyses on this subsample. The meta-analysis of all available studies revealed one statistically significant marker (rs558129 at GALNTL6 locus, p = 0.0002), even after correcting for multiple testing. As shown by the low heterogeneity index (I2 = 0), all eight cohorts showed the same direction of association with rs558129, even though p-values varied across the individual studies. In summary, this study did not identify a panel of genomic variants common to these elite endurance athlete groups. Since GAMES was underpowered to identify alleles with small effect sizes, some of the suggestive leads identified should be explored in expanded comparisons of world-class endurance athletes and sedentary controls and in tightly controlled exercise training studies. Such studies have the potential to illuminate the biology not only of world class endurance performance but also of compromised cardiac functions and cardiometabolic diseases.
dc.language.isoen
dc.publisherPublic Library of Science (PLoS)
dc.relation.ispartof
dc.relation.ispartofseriesPLOS ONE
dc.relation.urihttp://dx.doi.org/10.1371/journal.pone.0147330
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/
dc.subjectMeta-analysis
dc.subjectSports
dc.subjectGenome-wide association studies
dc.subjectGene mapping
dc.subjectGenetic loci
dc.subjectMolecular genetics
dc.subjectHuman performance
dc.subjectPhysical fitness
dc.titleNo Evidence of a Common DNA Variant Profile Specific to World Class Endurance Athletes
dc.description.versionpublished version
dc.contributor.departmentSchool of Medicine / Biomedicine
uef.solecris.id43047800en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Authors
dc.relation.projectid
dc.relation.doi10.1371/journal.pone.0147330
dc.description.reviewstatuspeerReviewed
dc.format.pagerange
dc.publisher.country
dc.relation.articlenumbere0147330
dc.relation.isbn
dc.relation.issn1932-6203
dc.relation.issue1
dc.relation.numberinseries
dc.relation.volume11
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessOpen access -julkaisukanavassa ilmestynyt julkaisu


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