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dc.contributor.authorDhungana H
dc.contributor.authorHuuskonen MT
dc.contributor.authorJaronen M
dc.contributor.authorLemarchant S
dc.contributor.authorAli H
dc.contributor.authorKeksa-Goldsteine V
dc.contributor.authorGoldsteins G
dc.contributor.authorKanninen KM
dc.contributor.authorKoistinaho J
dc.contributor.authorMalm T
dc.date.accessioned2018-01-31T07:05:10Z
dc.date.available2018-01-31T07:05:10Z
dc.date.issued2017
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/5781
dc.description.abstractBackground Ischemic stroke is one of the main causes of death and disability worldwide. It is caused by the cessation of cerebral blood flow resulting in the insufficient delivery of glucose and oxygen to the neural tissue. The inflammatory response initiated by ischemic stroke in order to restore tissue homeostasis in the acute phase of stroke contributes to delayed brain damage. Methods By using in vitro models of neuroinflammation and in vivo model of permanent middle cerebral artery occlusion, we demonstrate the neuroprotective and anti-inflammatory effects of sulfosuccinimidyl oleate sodium (SSO). Results SSO significantly reduced the lipopolysaccharide/interferon-γ-induced production of nitric oxide, interleukin-6 and tumor necrosis factor-α, and the protein levels of inflammatory enzymes including nitric oxide synthase 2, cyclooxygenase-2 (COX-2), and p38 mitogen-activated protein kinase (MAPK) in microglia, without causing cell toxicity. Although SSO failed to directly alleviate glutamate-induced excitotoxicity in murine cortical neurons, it prevented inflammation-induced neuronal death in microglia-neuron co-cultures. Importantly, oral administration of SSO in Balb/c mice subjected to permanent occlusion of the middle cerebral artery reduced microglial activation in the peri-ischemic area and attenuated brain damage. This in vivo neuroprotective effect of SSO was associated with a reduction in the COX-2 and heme oxygenase-1 immunoreactivities. Conclusions Our results suggest that SSO is an anti-inflammatory and a possible therapeutic candidate in diseases such as stroke where inflammation is a central hallmark.en
dc.language.isoENen
dc.publisherSpringer Natureen
dc.relation.ispartofseriesJOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/]en
dc.relation.urihttp://dx.doi.org/10.1186/s12974-017-1010-7en
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/en
dc.subjectStrokeen
dc.subjectCD36en
dc.subjectSSOen
dc.subjectInflammationen
dc.subjectMicrogliaen
dc.subjectNeuroprotectionen
dc.titleSulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammationen
dc.description.versionpublished versionen
dc.contributor.departmentA.I. Virtanen -instituuttien
uef.solecris.id51274188en
dc.type.publicationinfo:eu-repo/semantics/articleen
dc.rights.accessrights© Authorsen
dc.relation.doi10.1186/s12974-017-1010-7en
dc.description.reviewstatuspeerRevieweden
dc.relation.articlenumber237en
dc.relation.issn1742-2094en
dc.relation.issue11en
dc.relation.volume14en
dc.rights.accesslevelopenAccessen
dc.type.okmA1en
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
uef.solecris.openaccessOpen access -julkaisukanavassa ilmestynyt julkaisu


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