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dc.contributor.authorSingh, SP
dc.contributor.authorParviainen, I
dc.contributor.authorDekker, H
dc.contributor.authorSchulten, EAJM
dc.contributor.authorten Bruggenkate, CM
dc.contributor.authorBravenboer, N
dc.contributor.authorMikkonen, JJ
dc.contributor.authorTurunen, MJ
dc.contributor.authorKoistinen, AP
dc.contributor.authorKullaa, A
dc.date.accessioned2016-06-13T06:44:27Z
dc.date.available2016-06-13T06:44:27Z
dc.date.issued2015-09-14
dc.identifier10.4172/2155-9872.1000276
dc.identifier.citationSingh SP, Parviainen I, Dekker H, Schulten EAJM, ten Bruggenkate CM, et al. (2015) Raman Microspectroscopy Demonstrates Alterations in Human Mandibular Bone after Radiotherapy. J Anal Bioanal Tech 6:276. doi:10.4172/2155-9872.1000276fi_FI
dc.identifier.issn2155-9872
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/60
dc.descriptionArticle
dc.description.abstractQuality and alterations in the biochemical composition of bones used for dental implantation after radiotherapy in cancer patients is always a critical and debatable factor. Clinically the irradiated bone is similar to control bone. The aim of this study was to verify any compositional alterations in human mandible bone after irradiation using Raman microspectroscopy. A total of 36 bone biopsies (21-control, 4-cancer and 11-irradiated) were investigated. Data acquisition points were determined under histopathological supervision. Both mineral and matrix constituents were analyzed by computing area associated with of phosphate (958 cm-1), carbonate (1070 cm-1) and matrix (amide I) bands. Unpaired Student’s t-test was employed to measure level of significance. Absolute mineral contents (phosphate and carbonate) were highest in cancerous specimens. Spectral profile and band-intensity calculations suggest proximity of irradiated specimens with control specimens. Significant differences in both matrix and mineral contents were observed when control/irradiated samples were compared against cancerous specimens. However, no significant differences were observed between control and irradiated groups. Irradiated bone is similar to control and cause of implant loss could be related to osteocytes of the surrounding tissue.fi_FI
dc.language.isoenfi_FI
dc.publisherOMICS Publishing Groupfi_FI
dc.relation.ispartofseriesJournal of Analytical & Bioanalytical Techniques
dc.relation.urihttp://dx.doi.org/10.4172/2155-9872.1000276
dc.rightsCC BY 2.0 https://creativecommons.org/licenses/by/2.0/
dc.subjectRaman spectroscopyfi_FI
dc.subjectOral cancerfi_FI
dc.subjectMandiblefi_FI
dc.subjectRadiotherapyfi_FI
dc.subjectBonefi_FI
dc.titleRaman Microspectroscopy Demonstrates Alterations in Human Mandibular Bone after Radiotherapyfi_FI
dc.typehttp://purl.org/eprint/type/JournalArticle
dc.description.versionPublisher's pdf
dc.contributor.departmentFaculty of Science and Forestry
uef.solecris.id36517243
eprint.statushttp://purl.org/eprint/status/PeerReviewed
dc.type.publicationinfo:eu-repo/semantics/article
dc.rights.accessrights© Authors
dc.relation.doi10.4172/2155-9872.1000276
dc.description.reviewstatushttp://purl.org/eprint/status/PeerReviewed
dc.relation.issn2155-9872
dc.rights.accesslevelopenAccess


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