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dc.contributor.authorMcMahon Dallan
dc.contributor.authorBendayan Reina
dc.contributor.authorHynynen Kullervo
dc.date.accessioned2018-02-20T11:51:27Z
dc.date.available2018-02-20T11:51:27Z
dc.date.issued2017
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/6114
dc.description.abstractTherapeutic treatment options for central nervous system diseases are greatly limited by the blood-brain barrier (BBB). Focused ultrasound (FUS), in conjunction with circulating microbubbles, can be used to induce a targeted and transient increase in BBB permeability, providing a unique approach for the delivery of drugs from the systemic circulation into the brain. While preclinical research has demonstrated the utility of FUS, there remains a large gap in our knowledge regarding the impact of sonication on BBB gene expression. This work is focused on investigating the transcriptional changes in dorsal hippocampal rat microvessels in the acute stages following sonication. Microarray analysis of microvessels was performed at 6 and 24 hrs post-FUS. Expression changes in individual genes and bioinformatic analysis suggests that FUS may induce a transient inflammatory response in microvessels. Increased transcription of proinflammatory cytokine genes appears to be short-lived, largely returning to baseline by 24 hrs. This observation may help to explain some previously observed bioeffects of FUS and may also be a driving force for the angiogenic processes and reduced drug efflux suggested by this work. While further studies are necessary, these results open up intriguing possibilities for novel FUS applications and suggest possible routes for pharmacologically modifying the technique.en
dc.language.isoENen
dc.publisherSpringer Natureen
dc.relation.ispartofseriesScientific Reportsen
dc.relation.urihttp://dx.doi.org/10.1038/srep45657en
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/en
dc.subjectBlood–brain barrieren
dc.subjectNeurologyen
dc.subjectTranscriptomicsen
dc.titleAcute effects of focused ultrasound-induced increases in blood-brain barrier permeability on rat microvascular transcriptomeen
dc.description.versionpublished versionen
dc.contributor.departmentDepartment of Applied Physics, activitiesen
uef.solecris.id52578544en
dc.type.publicationinfo:eu-repo/semantics/articleen
dc.rights.accessrights© Authorsen
dc.relation.doi10.1038/srep45657en
dc.description.reviewstatuspeerRevieweden
dc.relation.articlenumber45657en
dc.relation.issn2045-2322en
dc.relation.volume7en
dc.rights.accesslevelopenAccessen
dc.type.okmA1en
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
uef.solecris.openaccessOpen access -julkaisukanavassa ilmestynyt julkaisu


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