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dc.contributor.authorSoininen, Sonja
dc.contributor.authorSidoroff, Virpi
dc.contributor.authorLindi, Virpi
dc.contributor.authorMahonen, Anitta
dc.contributor.authorKröger, Liisa
dc.contributor.authorKröger, Heikki
dc.contributor.authorJääskeläinen, Jarmo
dc.contributor.authorAtalay, Mustafa
dc.contributor.authorLaaksonen, David E
dc.contributor.authorLaitinen, Tomi
dc.contributor.authorLakka, Timo A
dc.date.accessioned2018-02-21T10:08:48Z
dc.date.available2018-02-21T10:08:48Z
dc.date.issued2018
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/6125
dc.description.abstractLean body mass (LM) has been positively associated with bone mineral density (BMD) in children and adolescents, but the relationship between body fat mass (FM) and BMD remains controversial. Several biomarkers secreted by adipose tissue, skeletal muscle, or bone may affect bone metabolism and BMD. We investigated the associations of LM, FM, and such biomarkers with BMD in children. We studied a population sample of 472 prepubertal Finnish children (227 girls, 245 boys) aged 6–8 years. We assessed BMD, LM, and FM using whole-body dual-energy x-ray absorptiometry and analysed several biomarkers from fasting blood samples. We studied the associations of LM, FM, and the biomarkers with BMD of the whole body excluding the head using linear regression analysis. LM (standardized regression coefficient β = 0.708, p < 0.001), FM (β = 0.358, p < 0.001), and irisin (β = 0.079, p = 0.048) were positive correlates for BMD adjusted for age, sex, and height in all children. These associations remained statistically significant after further adjustment for LM or FM. The positive associations of dehydroepiandrosterone sulphate (DHEAS), insulin, homeostatic model assessment for insulin resistance (HOMA-IR), leptin, free leptin index, and high-sensitivity C-reactive protein and the negative association of leptin receptor with BMD were explained by FM. The positive associations of DHEAS and HOMA-IR with BMD were also explained by LM. Serum 25-hydroxyvitamin D was a positive correlate for BMD adjusted for age, sex, and height and after further adjustment for FM but not for LM. LM and FM were positive correlates for BMD also in girls and boys separately. In girls, insulin, HOMA-IR, leptin, and free leptin index were positively and leptin receptor was negatively associated with BMD adjusted for age, height, and LM. After adjustment for age, height, and FM, none of the biomarkers was associated with BMD. In boys, leptin and free leptin index were positively and leptin receptor was negatively associated with BMD adjusted for age, height, and LM. After adjustment for age, height and FM, 25(OH)D was positively and IGF-1 and leptin were negatively associated with BMD. FM strongly modified the association between leptin and BMD. LM but also FM were strong, independent positive correlates for BMD in all children, girls, and boys. Irisin was positively and independently associated with BMD in all children. The associations of other biomarkers with BMD were explained by LM or FM.en
dc.language.isoENen
dc.publisherElsevier BVen
dc.relation.ispartofseriesBONEen
dc.relation.urihttp://dx.doi.org/10.1016/j.bone.2018.01.003en
dc.rightsCC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectBone mineral densityen
dc.subjectLean body massen
dc.subjectBody fat massen
dc.subjectDXAen
dc.subjectChilden
dc.subjectCytokineen
dc.titleBody fat mass, lean body mass and associated biomarkers as determinants of bone mineral density in children 6-8 years of age - The Physical Activity and Nutrition in Children (PANIC) studyen
dc.description.versionfinal draften
dc.contributor.departmentFaculty of Health Sciences, shared activities,School of Medicine / Clinical Medicineen
uef.solecris.id51832323en
dc.type.publicationarticleen
dc.rights.accessrights© Elsevier Inc.en
dc.relation.doi10.1016/j.bone.2018.01.003en
dc.description.reviewstatuspeerRevieweden
dc.format.pagerange106-114en
dc.relation.issn8756-3282en
dc.relation.volume108en
dc.rights.accesslevelopenAccessen
dc.type.okmA1en
dc.type.versioninfo:eu-repo/semantics/acceptedVersionen


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