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dc.contributor.authorVenäläinen Mikko S
dc.contributor.authorMononen Mika E
dc.contributor.authorSalo Jari
dc.contributor.authorRäsänen Lasse P
dc.contributor.authorJurvelin Jukka S
dc.contributor.authorTöyräs Juha
dc.contributor.authorVirén Tuomas
dc.contributor.authorKorhonen Rami K
dc.date.accessioned2018-02-23T09:33:57Z
dc.date.available2018-02-23T09:33:57Z
dc.date.issued2016
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/6141
dc.description.abstractFocal cartilage lesions can proceed to severe osteoarthritis or remain unaltered even for years. A method to identify high risk defects would be of utmost importance to guide clinical decision making and to identify the patients that are at the highest risk for the onset and progression of osteoarthritis. Based on cone beam computed tomography arthrography, we present a novel computational model for evaluating changes in local mechanical responses around cartilage defects. Our model, based on data obtained from a human knee in vivo, demonstrated that the most substantial alterations around the defect, as compared to the intact tissue, were observed in minimum principal (compressive) strains and shear strains. Both strain values experienced up to 3-fold increase, exceeding levels previously associated with chondrocyte apoptosis and failure of collagen crosslinks. Furthermore, defects at the central regions of medial tibial cartilage with direct cartilage-cartilage contact were the most vulnerable to loading. Also locations under the meniscus experienced substantially increased minimum principal strains. We suggest that during knee joint loading particularly minimum principal and shear strains are increased above tissue failure limits around cartilage defects which might lead to osteoarthritis. However, this increase in strains is highly location-specific on the joint surface.en
dc.language.isoENen
dc.publisherSpringer Natureen
dc.relation.ispartofseriesScientific Reportsen
dc.relation.urihttp://dx.doi.org/10.1038/srep37538en
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/en
dc.subjectComputational biophysicsen
dc.subjectOsteoarthritisen
dc.subjectTranslational researchen
dc.titleQuantitative Evaluation of the Mechanical Risks Caused by Focal Cartilage Defects in the Kneeen
dc.description.versionpublished versionen
dc.contributor.departmentDepartment of Applied Physics, activitiesen
uef.solecris.id44075153en
dc.type.publicationinfo:eu-repo/semantics/articleen
dc.rights.accessrights© Authorsen
dc.relation.doi10.1038/srep37538en
dc.description.reviewstatuspeerRevieweden
dc.relation.articlenumber37538en
dc.relation.issn2045-2322en
dc.relation.volume6en
dc.rights.accesslevelopenAccessen
dc.type.okmA1en
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
uef.solecris.openaccessOpen access -julkaisukanavassa ilmestynyt julkaisu


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