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Finnish Diabetes Risk Score Is Associated with Impaired Insulin Secretion and Insulin Sensitivity, Drug-Treated Hypertension and Cardiovascular Disease: A Follow-Up Study of the METSIM Cohort

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Date
2016
Author(s)
Fizelova Maria
Jauhiainen Raimo
Stancáková Alena
Kuusisto Johanna
Laakso Markku
Unique identifier
10.1371/journal.pone.0166584
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Citation
Fizelova Maria. Jauhiainen Raimo. Stancáková Alena. Kuusisto Johanna. Laakso Markku. (2016). Finnish Diabetes Risk Score Is Associated with Impaired Insulin Secretion and Insulin Sensitivity, Drug-Treated Hypertension and Cardiovascular Disease: A Follow-Up Study of the METSIM Cohort.  PLOS ONE, 11 (11) , e0166584. 10.1371/journal.pone.0166584.
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CC BY http://creativecommons.org/licenses/by/4.0/
Abstract

We investigated the association of the Finnish Diabetes Risk Score (FINDRISC) with insulin secretion, insulin sensitivity, and risk of type 2 diabetes, drug-treated hypertension, cardiovascular (CVD) events and total mortality in a follow-up study of the Metabolic Syndrome in Men (METSIM) cohort. The METSIM study includes 10,197 Finnish men, aged 45–73 years, and examined in 2005–2010. Of 8,749 non-diabetic participants of the METSIM study 693 developed incident type 2 diabetes, 225 started antihypertensive medication, 351 had a CVD event, and 392 died during a 8.2-year follow-up. The FINDRISC was significantly associated with decreases in insulin secretion and insulin sensitivity (P<0.0001), and with a 4.14-fold increased risk of incident type 2 diabetes, 2.43-fold increased risk of drug-treated hypertension, 1.61-fold increased risk of CVD, and 1.55-increased risk of total mortality (the FINDRISC ≥12 vs. < 12 points). In conclusion, the FINDRISC predicts impairment in insulin secretion and insulin sensitivity, the conversion to type 2 diabetes, drug-treated hypertension, CVD events and total mortality.

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https://erepo.uef.fi/handle/123456789/6142
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http://dx.doi.org/10.1371/journal.pone.0166584
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Public Library of Science (PLoS)
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  • Terveystieteiden tiedekunta [1335]
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