Show simple item record

dc.contributor.authorFizelova Maria
dc.contributor.authorJauhiainen Raimo
dc.contributor.authorStancáková Alena
dc.contributor.authorKuusisto Johanna
dc.contributor.authorLaakso Markku
dc.date.accessioned2018-02-23T11:24:41Z
dc.date.available2018-02-23T11:24:41Z
dc.date.issued2016
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/6142
dc.description.abstractWe investigated the association of the Finnish Diabetes Risk Score (FINDRISC) with insulin secretion, insulin sensitivity, and risk of type 2 diabetes, drug-treated hypertension, cardiovascular (CVD) events and total mortality in a follow-up study of the Metabolic Syndrome in Men (METSIM) cohort. The METSIM study includes 10,197 Finnish men, aged 45–73 years, and examined in 2005–2010. Of 8,749 non-diabetic participants of the METSIM study 693 developed incident type 2 diabetes, 225 started antihypertensive medication, 351 had a CVD event, and 392 died during a 8.2-year follow-up. The FINDRISC was significantly associated with decreases in insulin secretion and insulin sensitivity (P<0.0001), and with a 4.14-fold increased risk of incident type 2 diabetes, 2.43-fold increased risk of drug-treated hypertension, 1.61-fold increased risk of CVD, and 1.55-increased risk of total mortality (the FINDRISC ≥12 vs. < 12 points). In conclusion, the FINDRISC predicts impairment in insulin secretion and insulin sensitivity, the conversion to type 2 diabetes, drug-treated hypertension, CVD events and total mortality.en
dc.language.isoENen
dc.publisherPublic Library of Science (PLoS)en
dc.relation.ispartofseriesPLOS ONEen
dc.relation.urihttp://dx.doi.org/10.1371/journal.pone.0166584en
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/en
dc.titleFinnish Diabetes Risk Score Is Associated with Impaired Insulin Secretion and Insulin Sensitivity, Drug-Treated Hypertension and Cardiovascular Disease: A Follow-Up Study of the METSIM Cohorten
dc.description.versionpublished versionen
dc.contributor.departmentSchool of Medicine / Clinical Medicineen
uef.solecris.id44048381en
dc.type.publicationinfo:eu-repo/semantics/articleen
dc.rights.accessrights© Authorsen
dc.relation.doi10.1371/journal.pone.0166584en
dc.description.reviewstatuspeerRevieweden
dc.relation.articlenumbere0166584en
dc.relation.issn1932-6203en
dc.relation.issue11en
dc.relation.volume11en
dc.rights.accesslevelopenAccessen
dc.type.okmA1en
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
uef.solecris.openaccessOpen access -julkaisukanavassa ilmestynyt julkaisu


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record