Show simple item record

dc.contributor.authorWang A
dc.contributor.authorArah OA
dc.contributor.authorKauhanen J
dc.contributor.authorKrause N
dc.date.accessioned2018-02-26T08:14:31Z
dc.date.available2018-02-26T08:14:31Z
dc.date.issued2016
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/6152
dc.description.abstractObjectives: This study aimed to disentangle the interplay between occupational physical activity (OPA) and leisure-time physical activity (LTPA) in affecting cardiovascular health by examining: (i) interactions between OPA and LTPA and their combined effect on 20-year incidence of acute myocardial infarction (AMI) and (ii) the effect of OPA on AMI that is mediated through LTPA. Methods: We analyzed data on 1891 men, aged 42–60 years at baseline, from the prospective Kuopio Ischemic Heart Disease Risk Factor Study. OPA was measured as relative aerobic strain (RAS), accounting for workers’ cardiorespiratory fitness. Averaged 12-month LTPA and potential confounders were assessed by questionnaires. Analyses were stratified by the presence of ischemic heart disease (IHD) at baseline. Results: We found potential multiplicative, but not additive, interactions between OPA and LTPA among men with IHD. The multivariable Cox model, adjusted for age, education, smoking, alcohol consumption, psychosocial job factors, and participation in an unrelated drug trial, showed that high OPA positively predicted AMI at low LTPA levels for both men with and without IHD: hazard ratio (HR) 1.27 [95% confidence interval (95% CI) 0.96–1.68] and HR 1.59 (95% CI 0.99–1.68), respectively. The combination of high OPA and low LTPA constituted the group associated with the highest risk for AMI, irrespective of IHD status. LTPA was not independently predictive of AMI and did not mediate the impact of OPA on AMI. Conclusions: LTPA interacted with OPA on the multiplicative scale only. LTPA did not mediate the effect of OPA on AMI.en
dc.language.isoENen
dc.publisherScandinavian Journal of Work, Environment and Healthen
dc.relation.ispartofseriesSCANDINAVIAN JOURNAL OF WORK, ENVIRONMENT AND HEALTHen
dc.relation.urihttp://dx.doi.org/10.5271/sjweh.3580en
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/en
dc.subjectacute myocardial infarctionen
dc.subjectcoronary heart diseaseen
dc.subjecteffect modificationen
dc.subjectenergy expenditureen
dc.subjectepidemiologyen
dc.subjectIHDen
dc.subjectinteractionen
dc.subjectischemic heart diseaseen
dc.subjectleisure-timeen
dc.subjectmediationen
dc.subjectoccupational healthen
dc.subjectoccupational physical activityen
dc.subjectphysical activityen
dc.subjectpopulation-based studyen
dc.subjectprospective studyen
dc.subjectrelative aerobic strainen
dc.subjectrelative aerobic workloaden
dc.titleEffects of leisure-time and occupational physical activities on 20-year incidence of acute myocardial infarction: mediation and interactionen
dc.description.versionpublished versionen
dc.contributor.departmentSchool of Medicine / Public Healthen
uef.solecris.id43993118en
dc.type.publicationinfo:eu-repo/semantics/articleen
dc.rights.accessrights© Scandinavian Journal of Work, Environment & Healthen
dc.relation.doi10.5271/sjweh.3580en
dc.description.reviewstatuspeerRevieweden
dc.format.pagerange423-434en
dc.relation.issn0355-3140en
dc.relation.issue5en
dc.relation.volume42en
dc.rights.accesslevelopenAccessen
dc.type.okmA1en
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
uef.solecris.openaccessHybridijulkaisukanavassa ilmestynyt avoin julkaisu


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record