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dc.contributor.authorGallini R
dc.contributor.authorHuusko J
dc.contributor.authorYlä-Herttuala S
dc.contributor.authorBetsholtz C
dc.contributor.authorAndrae J
dc.date.accessioned2018-02-26T09:33:39Z
dc.date.available2018-02-26T09:33:39Z
dc.date.issued2016
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/6161
dc.description.abstractPlatelet-derived growth factors (PDGFs) are key regulators of mesenchymal cells in vertebrate development. To what extent PDGFs also exert beneficial homeostatic or reparative roles in adult organs, as opposed to adverse fibrogenic responses in pathology, are unclear. PDGF signaling plays critical roles during heart development, during which forced overexpression of PDGFs induces detrimental cardiac fibrosis; other studies have implicated PDGF signaling in post-infarct myocardial repair. Different PDGFs may exert different effects mediated through the two PDGF receptors (PDGFRα and PDGFRβ) in different cell types. Here, we assessed responses induced by five known PDGF isoforms in the adult mouse heart in the context of adenovirus vector-mediated inflammation. Our results show that different PDGFs have different, in some cases even opposing, effects. Strikingly, whereas the major PDGFRα agonists (PDGF-A and -C) decreased the amount of scar tissue and increased the numbers of PDGFRα-positive fibroblasts, PDGFRβ agonists either induced large scars with extensive inflammation (PDGF-B) or dampened the adenovirus-induced inflammation and produced a small and dense scar (PDGF-D). These results provide evidence for PDGF isoform-specific inflammation-modulating functions that may have therapeutic implications. They also illustrate a surprising complexity in the PDGF-mediated pathophysiological responses.en
dc.language.isoENen
dc.publisherPublic Library of Science (PLoS)en
dc.relation.ispartofseriesPLOS ONEen
dc.relation.urihttp://dx.doi.org/10.1371/journal.pone.0160930en
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/en
dc.titleIsoform-Specific Modulation of Inflammation Induced by Adenoviral Mediated Delivery of Platelet-Derived Growth Factors in the Adult Mouse Hearten
dc.description.versionpublished versionen
dc.contributor.departmentA.I. Virtanen -instituutti / Bioteknologia ja molekulaarinen lääketiedeen
uef.solecris.id44076687en
dc.type.publicationinfo:eu-repo/semantics/articleen
dc.rights.accessrights© Authorsen
dc.relation.doi10.1371/journal.pone.0160930en
dc.description.reviewstatuspeerRevieweden
dc.relation.articlenumbere0160930en
dc.relation.issn1932-6203en
dc.relation.issue8en
dc.relation.volume11en
dc.rights.accesslevelopenAccessen
dc.type.okmA1en
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
uef.solecris.openaccessOpen access -julkaisukanavassa ilmestynyt julkaisu


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