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dc.contributor.authorPaasonen
dc.contributor.authorJaakko; Stenroos
dc.contributor.authorPetteri; Salo
dc.contributor.authorRaimo A; Kiviniemi
dc.contributor.authorVesa; Gröhn Olli
dc.date.accessioned2018-03-06T12:07:07Z
dc.date.available2018-03-06T12:07:07Z
dc.date.issued2018
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/6176
dc.description.abstractResting-state functional magnetic resonance imaging (rsfMRI) is a translational imaging method with great potential in several neurobiologic applications. Most preclinical rsfMRI studies are performed in anesthetized animals, but the confounding effects of anesthesia on the measured functional connectivity (FC) are poorly understood. Therefore, we measured FC under six commonly used anesthesia protocols and compared the findings with data obtained from awake rats. The results demonstrated that each anesthesia protocol uniquely modulated FC. Connectivity patterns obtained under propofol and urethane anesthesia were most similar to that observed in awake rats. FC patterns in the α-chloralose and isoflurane-medetomidine combination groups had moderate to good correspondence with that in the awake group. The FC patterns in the isoflurane and medetomidine groups differed most from that in the awake rats. These results can be directly exploited in rsfMRI study designs to improve the data quality, comparability, and interpretationen
dc.language.isoENen
dc.relation.ispartofseriesNEUROIMAGEen
dc.relation.urihttp://dx.doi.org/10.1016/j.neuroimage.2018.01.014en
dc.rightsCC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectAnestheticsen
dc.subjectAwakeen
dc.subjectFunctional connectivityen
dc.subjectMagnetic resonance imagingen
dc.subjectFunctionalen
dc.subjectRatsen
dc.titleFunctional connectivity under six anesthesia protocols and the awake condition in rat brainen
dc.description.versionpublished versionen
dc.contributor.departmentA.I. Virtanen -instituuttien
uef.solecris.id52607320en
dc.type.publicationinfo:eu-repo/semantics/articleen
dc.rights.accessrights© Elsevier Inc.en
dc.relation.doi10.1016/j.neuroimage.2018.01.014en
dc.description.reviewstatuspeerRevieweden
dc.format.pagerange9-20en
dc.relation.issn1053-8119en
dc.relation.volume172en
dc.rights.accesslevelopenAccessen
dc.type.okmA1en
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
uef.solecris.openaccessHybridijulkaisukanavassa ilmestynyt avoin julkaisu


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