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dc.contributor.authorTwardziok M
dc.contributor.authorSchröder PC
dc.contributor.authorKrusche J
dc.contributor.authorCasaca VI
dc.contributor.authorIlli S
dc.contributor.authorBöck A
dc.contributor.authorLoss GJ
dc.contributor.authorKabesch M
dc.contributor.authorToncheva A
dc.contributor.authorRoduit C
dc.contributor.authorDepner M
dc.contributor.authorGenuneit J
dc.contributor.authorRenz H
dc.contributor.authorRoponen M
dc.contributor.authorWeber J
dc.contributor.authorBraun-Fahrländer C
dc.contributor.authorRiedler J
dc.contributor.authorLauener R
dc.contributor.authorVuitton DA
dc.contributor.authorDalphin JC et al.
dc.contributor.authorthe PASTURE Study Group
dc.date.accessioned2018-03-23T11:46:46Z
dc.date.available2018-03-23T11:46:46Z
dc.date.issued2017
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/6206
dc.description.abstractSeveral studies report an important role of CD8+ cytotoxic T-cells in atopy. Farm children show protection against atopy development, partly explained by CD4+ T-cell subtypes. Additional effects of CD8+ T-cells are unknown being investigated in this study within the PASTURE/EFRAIM birth cohort in PBMCs from farming and non-farming 6-year-old (N = 76) German children. CD3+ CD8+ CD25+ T-cells were analyzed by flow cytometry. Genotyping of 17q21 locus-SNPs associated with childhood asthma was performed. No differences in CD8+ T-cell subsets were seen between farmers and non-farmers regardless of asthma. Among farm children, asthmatics displayed increased CD3+ CD8low(CD25+) T-cells compared to non-asthmatics. Asthmatic farm children exhibited a lower PI-induced stimulatory capacity of CD3+ CD8low(CD25+) cells and a lower IFN-γ secretion than non-asthmatic farm children. Among farm children with GSDMB and ORMDL3 risk alleles, asthmatics displayed higher CD3+ CD8low cells than non-asthmatics. Our data indicates a specific role of CD8low T-cells in asthmatic farm children.
dc.language.isoEN
dc.publisherElsevier BV
dc.relation.ispartofseriesClinical Immunology
dc.relation.urihttp://dx.doi.org/10.1016/j.clim.2017.09.009
dc.rightsCC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectCD8+
dc.subjectCD8low
dc.subjectChildhood
dc.subjectFarm-exposure
dc.titleAsthmatic farm children show increased CD3+CD8low T-cells compared to non-asthmatic farm children
dc.description.versionfinal draft
dc.contributor.departmentYmpäristö- ja biotieteiden laitos / Toiminta
uef.solecris.id49613923en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Elsevier Inc
dc.relation.doi10.1016/j.clim.2017.09.009
dc.description.reviewstatuspeerReviewed
dc.format.pagerange285-292
dc.relation.issn1521-6616
dc.relation.volume183
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessEi


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