Hemoglobin level and lipoprotein particle size
Files
Self archived version
published versionDate
2018Author(s)
Unique identifier
10.1186/s12944-018-0655-2Metadata
Show full item recordMore information
Self-archived item
Citation
Hämäläinen, P. Saltevo, J. Kautiainen, H. Mäntyselkä, P. Vanhala, M. (2018). Hemoglobin level and lipoprotein particle size. Lipids in Health and Disease, 17, 10. 10.1186/s12944-018-0655-2.Rights
Abstract
Background
Alterations in lipoprotein size are associated with increased cardiovascular disease risk. Higher hemoglobin levels may indicate a higher risk of atherosclerosis and was previously associated with obesity, metabolic syndrome, and insulin resistance. No previous studies have investigated an association between hemoglobin concentration and lipoprotein particle size.
Methods
We conducted a population-based, cross-sectional study of 766 Caucasian, middle-aged subjects (341 men and 425 women) born in Pieksämäki, Finland, who were categorized into five age groups. The concentrations and sizes of lipoprotein subclass particles were analyzed by high-throughput nuclear magnetic resonance (NMR) spectroscopy.
Results
Larger very low density lipoprotein (VLDL) particle diameter was associated with higher hemoglobin concentrations in men (p = 0.003). There was a strong relationship between smaller high density lipoprotein (HDL) particle size and higher hemoglobin concentration in both men and women as well as with smaller low density lipoprotein (LDL) particle size and higher hemoglobin concentration in men and women (p < 0.001; p = 0.009, p = 0.008). VLDL particle concentration had a moderate positive correlation with hemoglobin concentration (r = 0.15; p < 0.001). LDL particle concentration showed a statistical trend suggesting increasing particle concentration with increasing hemoglobin levels (r = 0.08; p = 0.05).
Conclusion
Higher hemoglobin levels are associated with larger VLDL, smaller LDL, and smaller HDL particle sizes and increasing amounts of larger VLDL and smaller LDL particles. This suggests that a higher hemoglobin concentration is associated with an unfavorable lipoprotein particle profile that is part of states that increase cardiovascular disease risk like diabetes and metabolic syndrome.
Keywords
Link to the original item
http://dx.doi.org/10.1186/s12944-018-0655-2Publisher
Springer NatureCollections
- Terveystieteiden tiedekunta [1735]