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dc.contributor.authorArponen, O
dc.contributor.authorSudah, M
dc.contributor.authorSutela, A
dc.contributor.authorTaina, M
dc.contributor.authorMasarwah, A
dc.contributor.authorLiimatainen, T
dc.contributor.authorVanninen, R
dc.date.accessioned2018-04-06T11:52:28Z
dc.date.available2018-04-06T11:52:28Z
dc.date.issued2018
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/6222
dc.description.abstractTo retrospectively evaluated the influence of administration of the gadolinium based intravenous contrast agent (G-CA) on apparent diffusion coefficient (ADC) values in ADC maps generated using multiple b value combinations. A total of 106 women underwent bilateral 3.0 T breast MRI. As an internal validation, diffusion-weighted imaging (b values of 0, 200, 400, 600, 800 s/mm2) was performed before and after the G-CA (gadoterate meglumine (0.2 ml/kg, 3 ml/s)). Whole lesion and fibroglandular tissue (FGT) covering region-of-interests (ROIs) were drawn on the b = 800 s/mm2 images; ROIs were then propagated to multiple retrospectively generated ADC maps. Twenty-seven patients (mean age 55.8 ± 10.8 years) with 32 mass-like enhancing breast lesions including 25 (78.1 %) histopathologically malignant lesions were enrolled. Lesion ADC values were statistically significantly higher in pre-G-CA than post-G-CA ADC maps (ADC0,200,400,600,800: 1.05 ± 0.35 × 10−3 mm2/s vs. 1.02 ± 0.36 × 10−3 mm2/s (P < 0.05); ADC0,200,400: 1.25 ± 0.42 × 10−3 mm2/s vs. 1.20 ± 0.35 × 10−3 mm2/s (P < 0.05)). ADC values between pre- and post-contrast maps were not statistically different when the maps were generated using other b value combinations. Contrast agent administration did not affect the FGT ADC values. G-CA statistically significantly reduced the ADC values of breast lesions on ADC maps generated using the clinically widely utilized b values.
dc.language.isoEN
dc.publisherSpringer Nature
dc.relation.ispartofseriesScientific Reports
dc.relation.urihttp://dx.doi.org/10.1038/s41598-017-18035-0
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/
dc.subjectmedical research
dc.subjecttranslational research
dc.titleGadoterate meglumine decreases ADC values of breast lesions depending on the b value combination
dc.description.versionpublished version
dc.contributor.departmentSchool of Medicine / Clinical Medicine
uef.solecris.id51952627en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Authors
dc.relation.doi10.1038/s41598-017-18035-0
dc.description.reviewstatuspeerReviewed
dc.relation.articlenumber87
dc.relation.issn2045-2322
dc.relation.volume8
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessOpen access -julkaisukanavassa ilmestynyt julkaisu


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