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dc.contributor.authorRenko, Outi
dc.contributor.authorTolonen, Anna-Maria
dc.contributor.authorRysä, Jaana
dc.contributor.authorMagga, Johanna
dc.contributor.authorMustonen, Erja
dc.contributor.authorRuskoaho, Heikki
dc.contributor.authorSerpi, Raisa
dc.date.accessioned2018-04-06T12:20:13Z
dc.date.available2018-04-06T12:20:13Z
dc.date.issued2018
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/6228
dc.description.abstractIdentification of the adult cardiac stem cells (CSCs) has offered new therapeutic possibilities for treating ischemic myocardium. CSCs positive for the cell surface antigen c-Kit are known as the primary source for cardiac regeneration. Accumulating evidence shows that chemokines play important roles in stem cell homing. Here we investigated molecular targets to be utilized in modulating the mobility of endogenous CSCs. In a four week follow-up after experimental acute myocardial infarction (AMI) with ligation of the left anterior descending (LAD) coronary artery of Sprague-Dawley rats c-Kit+ CSCs redistributed in the heart. The number of c-Kit+ CSCs in the atrial c-Kit niche was diminished, whereas increased amount was observed in the left ventricle and apex. This was associated with increased expression of stromal cell-derived factor 1 alpha (SDF1α), and a significant positive correlation was found between c-Kit+ CSCs and SDF1α expression in the heart. Moreover, the migratory capacity of isolated c-Kit+ CSCs was induced by SDF1 treatment in vitro. We conclude that upregulation of SDF1α after AMI associates with increased expression of endogenous c-Kit+ CSCs in the injury area, and show induced migration of c-Kit+ cells by SDF1.
dc.language.isoEN
dc.publisherSpringer Nature
dc.relation.ispartofseriesScientific Reports
dc.relation.urihttp://dx.doi.org/10.1038/s41598-018-19417-8
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/
dc.subjectmolecular biology
dc.subjectmolecular medicine
dc.titleSDF1 gradient associates with the distribution of c-Kit+ cardiac cells in the heart
dc.description.versionpublished version
dc.contributor.departmentSchool of Pharmacy, Activities
uef.solecris.id52133008en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Authors
dc.relation.doi10.1038/s41598-018-19417-8
dc.description.reviewstatuspeerReviewed
dc.relation.articlenumber1160
dc.relation.issn2045-2322
dc.relation.volume8
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessOpen access -julkaisukanavassa ilmestynyt julkaisu


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