Show simple item record

dc.contributor.authorJokinen Jussi
dc.contributor.authorKönigsson Johan
dc.contributor.authorMoberg Tomas
dc.contributor.authorJönsson Erik G
dc.contributor.authorTiihonen Jari
dc.contributor.authorNordström Peter
dc.contributor.authorOreland Lars
dc.contributor.authorÅsberg Marie
dc.date.accessioned2018-04-09T08:30:53Z
dc.date.available2018-04-09T08:30:53Z
dc.date.issued2018
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/6234
dc.description.abstractLow platelet monoamine oxidase B (MAO-B) activity, proxy of low central serotonergic functions, has been shown to correlate with criminal behavior in adolescents that come from an unfavorable psychosocial environment but not in adolescents from good conditions, indicating a link between environment, MAO-B activity and aggressive behavior. The purpose of this study was to examine the association between MAO-B activity and lifetime interpersonal violence in suicide attempters. The study included a total of 28 suicide attempters (18 men and 10 women). Assessments of childhood exposure to and expressed interpersonal violence during childhood and as an adult were carried out with the Karolinska Interpersonal Violence Scale (KIVS). Platelet MAO-B activity was measured with 2-phenylethylamine (b-PEA) as substrate. Broken down by gender, the correlations between platelet MAO-B activity and both exposure scores to interpersonal violence as a child and expressed lifetime interpersonal violence were significant in male suicide attempters (r = −0.61, p = 0.035; r = −0.84, p = 0.0005), but not in women. Our finding of significant associations between interpersonal violence and low MAO-B activity need to be replicated in other cohorts of suicide attempters.
dc.language.isoEN
dc.publisherElsevier BV
dc.relation.ispartofseriesPSYCHIATRY RESEARCH
dc.relation.urihttp://dx.doi.org/10.1016/j.psychres.2017.11.057
dc.rightsCC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectMAO-B
dc.subjectserotonin
dc.subjectsuicide
dc.subjectviolence
dc.subjectearly life adversity
dc.titlePlatelet monoamine oxidase activity and interpersonal violence in male suicide attempters
dc.description.versionfinal draft
dc.contributor.departmentSchool of Medicine / Clinical Medicine
uef.solecris.id50964305en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Elsevier B.V.
dc.relation.doi10.1016/j.psychres.2017.11.057
dc.description.reviewstatuspeerReviewed
dc.format.pagerange173-176
dc.relation.issn0165-1781
dc.relation.volume260
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessEi


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record