dc.contributor.author | Hilvo, M | |
dc.contributor.author | Salonurmi, T | |
dc.contributor.author | Havulinna, AS | |
dc.contributor.author | Kauhanen, D | |
dc.contributor.author | Pedersen, ER | |
dc.contributor.author | Tell, GS | |
dc.contributor.author | Meyer, K | |
dc.contributor.author | Teeriniemi, AM | |
dc.contributor.author | Laatikainen, T | |
dc.contributor.author | Jousilahti, P | |
dc.contributor.author | Savolainen, MJ | |
dc.contributor.author | Nygård, O | |
dc.contributor.author | Salomaa, V | |
dc.contributor.author | Laaksonen, R | |
dc.date.accessioned | 2018-04-09T11:59:46Z | |
dc.date.available | 2018-04-09T11:59:46Z | |
dc.date.issued | 2018 | |
dc.identifier.uri | https://erepo.uef.fi/handle/123456789/6241 | |
dc.description.abstract | Aims/hypothesis
Ceramide lipids have a role in the development of insulin resistance, diabetes and risk of cardiovascular disease. Here we investigated four ceramides and their ratios to find the best predictors of incident diabetes.
Methods
A validated mass-spectrometric method was applied to measure Cer(d18:1/16:0), Cer(d18:1/18:0), Cer(d18:1/24:0) and Cer(d18:1/24:1) from serum or plasma samples. These ceramides were analysed in a population-based risk factor study (FINRISK 2002, n = 8045), in a cohort of participants undergoing elective coronary angiography for suspected stable angina pectoris (Western Norway Coronary Angiography Cohort [WECAC], n = 3344) and in an intervention trial investigating improved methods of lifestyle modification for individuals at high risk of the metabolic syndrome (Prevent Metabolic Syndrome [PrevMetSyn], n = 371). Diabetes risk score models were developed to estimate the 10 year risk of incident diabetes.
Results
Analysis in FINRISK 2002 showed that the Cer(d18:1/18:0)/Cer(d18:1/16:0) ceramide ratio was predictive of incident diabetes (HR per SD 2.23, 95% CI 2.05, 2.42), and remained significant after adjustment for several risk factors, including BMI, fasting glucose and HbA1c (HR 1.34, 95% CI 1.14, 1.57). The finding was validated in the WECAC study (unadjusted HR 1.81, 95% CI 1.53, 2.14; adjusted HR 1.39, 95% CI 1.16, 1.66). In the intervention trial, the ceramide ratio and diabetes risk scores significantly decreased in individuals who had 5% or more weight loss.
Conclusions/interpretation
The Cer(d18:1/18:0)/Cer(d18:1/16:0) ratio is an independent predictive biomarker for incident diabetes, and may be modulated by lifestyle intervention. | |
dc.language.iso | EN | |
dc.relation.ispartofseries | DIABETOLOGIA | |
dc.relation.uri | http://dx.doi.org/10.1007/s00125-018-4590-6 | |
dc.rights | CC BY 4.0 | |
dc.subject | ceramide | |
dc.subject | diabetes | |
dc.subject | palmitic acid | |
dc.subject | prediction | |
dc.subject | prevention | |
dc.subject | risk | |
dc.subject | stearic acid | |
dc.title | Ceramide stearic to palmitic acid ratio predicts incident diabetes | |
dc.description.version | published version | |
dc.contributor.department | School of Medicine / Public Health | |
uef.solecris.id | 53271341 | en |
dc.type.publication | Tieteelliset aikakauslehtiartikkelit | |
dc.relation.doi | 10.1007/s00125-018-4590-6 | |
dc.description.reviewstatus | peerReviewed | |
dc.format.pagerange | 1424–1434 | |
dc.publisher.country | Saksa | |
dc.relation.issn | 0012-186X | |
dc.relation.issue | 6 | |
dc.relation.volume | 61 | |
dc.rights.accesslevel | openAccess | |
dc.type.okm | A1 | |
uef.solecris.openaccess | Hybridijulkaisukanavassa ilmestynyt avoin julkaisu | |
dc.rights.copyright | © Authors | |
dc.type.displayType | article | en |
dc.type.displayType | artikkeli | fi |
dc.rights.url | https://creativecommons.org/licenses/by/4.0/ | |