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dc.contributor.authorHilvo, M
dc.contributor.authorSalonurmi, T
dc.contributor.authorHavulinna, AS
dc.contributor.authorKauhanen, D
dc.contributor.authorPedersen, ER
dc.contributor.authorTell, GS
dc.contributor.authorMeyer, K
dc.contributor.authorTeeriniemi, AM
dc.contributor.authorLaatikainen, T
dc.contributor.authorJousilahti, P
dc.contributor.authorSavolainen, MJ
dc.contributor.authorNygård, O
dc.contributor.authorSalomaa, V
dc.contributor.authorLaaksonen, R
dc.date.accessioned2018-04-09T11:59:46Z
dc.date.available2018-04-09T11:59:46Z
dc.date.issued2018
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/6241
dc.description.abstractAims/hypothesis Ceramide lipids have a role in the development of insulin resistance, diabetes and risk of cardiovascular disease. Here we investigated four ceramides and their ratios to find the best predictors of incident diabetes. Methods A validated mass-spectrometric method was applied to measure Cer(d18:1/16:0), Cer(d18:1/18:0), Cer(d18:1/24:0) and Cer(d18:1/24:1) from serum or plasma samples. These ceramides were analysed in a population-based risk factor study (FINRISK 2002, n = 8045), in a cohort of participants undergoing elective coronary angiography for suspected stable angina pectoris (Western Norway Coronary Angiography Cohort [WECAC], n = 3344) and in an intervention trial investigating improved methods of lifestyle modification for individuals at high risk of the metabolic syndrome (Prevent Metabolic Syndrome [PrevMetSyn], n = 371). Diabetes risk score models were developed to estimate the 10 year risk of incident diabetes. Results Analysis in FINRISK 2002 showed that the Cer(d18:1/18:0)/Cer(d18:1/16:0) ceramide ratio was predictive of incident diabetes (HR per SD 2.23, 95% CI 2.05, 2.42), and remained significant after adjustment for several risk factors, including BMI, fasting glucose and HbA1c (HR 1.34, 95% CI 1.14, 1.57). The finding was validated in the WECAC study (unadjusted HR 1.81, 95% CI 1.53, 2.14; adjusted HR 1.39, 95% CI 1.16, 1.66). In the intervention trial, the ceramide ratio and diabetes risk scores significantly decreased in individuals who had 5% or more weight loss. Conclusions/interpretation The Cer(d18:1/18:0)/Cer(d18:1/16:0) ratio is an independent predictive biomarker for incident diabetes, and may be modulated by lifestyle intervention.
dc.language.isoEN
dc.relation.ispartofseriesDIABETOLOGIA
dc.relation.urihttp://dx.doi.org/10.1007/s00125-018-4590-6
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/
dc.subjectceramide
dc.subjectdiabetes
dc.subjectpalmitic acid
dc.subjectprediction
dc.subjectprevention
dc.subjectrisk
dc.subjectstearic acid
dc.titleCeramide stearic to palmitic acid ratio predicts incident diabetes
dc.description.versionpublished version
dc.contributor.departmentSchool of Medicine / Public Health
uef.solecris.id53271341en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Authors
dc.relation.doi10.1007/s00125-018-4590-6
dc.description.reviewstatuspeerReviewed
dc.publisher.countrySaksa
dc.relation.issn0012-186X
dc.relation.volumeFirst Online: 15 March 2018
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessHybridijulkaisukanavassa ilmestynyt avoin julkaisu


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