Skip to main contentSkip to search and navigation

UEF eREPOSITORY

    • English
    • suomi
  • English 
    • English
    • suomi
  • Login
View Item 
  •   Home
  • Artikkelit
  • Terveystieteiden tiedekunta
  • View Item
  •   Home
  • Artikkelit
  • Terveystieteiden tiedekunta
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics: The FINGER trial

Thumbnail
Files
Article (317.5Kb)
Self archived version
published version
Date
2018
Author(s)
Rosenberg, A
Ngandu, T
Rusanen, M
Antikainen, R
Bäckman, L
Havulinna, S
Hänninen, T
Laatikainen, T
Lehtisalo, J
Levälahti, E
Lindström, J
Paajanen, T
Peltonen, M
Soininen, H
Stigsdotter-Neely, A
Strandberg, T
Tuomilehto, J
Solomon, A
Kivipelto, M
Unique identifier
10.1016/j.jalz.2017.09.006
Metadata
Show full item record
More information
Research Database SoleCris

Self-archived article

Citation
Rosenberg, A. Ngandu, T. Rusanen, M. Antikainen, R. Bäckman, L. Havulinna, S. Hänninen, T. Laatikainen, T. Lehtisalo, J. Levälahti, E. Lindström, J. Paajanen, T. Peltonen, M. Soininen, H. Stigsdotter-Neely, A. Strandberg, T. Tuomilehto, J. Solomon, A. Kivipelto, M. (2018). Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics: The FINGER trial.  Alzheimer's & Dementia, 14 (3) , 263-270. 10.1016/j.jalz.2017.09.006.
Rights
© Authors
Licensed under
CC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/
Abstract

Introduction
The 2-year Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) multidomain lifestyle intervention trial (NCT01041989) demonstrated beneficial effects on cognition. We investigated whether sociodemographics, socioeconomic status, baseline cognition, or cardiovascular factors influenced intervention effects on cognition.

Methods
The FINGER recruited 1260 people from the general Finnish population (60–77 years, at risk for dementia). Participants were randomized 1:1 to multidomain intervention (diet, exercise, cognition, and vascular risk management) and regular health advice. Primary outcome was change in cognition (Neuropsychological Test Battery z-score). Prespecified analyses to investigate whether participants' characteristics modified response to intervention were carried out using mixed-model repeated-measures analyses.

Results
Sociodemographics (sex, age, and education), socioeconomic status (income), cognition (Mini–Mental State Examination), cardiovascular factors (body mass index, blood pressure, cholesterol, fasting glucose, and overall cardiovascular risk), and cardiovascular comorbidity did not modify response to intervention (P-values for interaction > .05).

Conclusions
The FINGER intervention was beneficial regardless of participants' characteristics and can thus be implemented in a large elderly population at increased risk for dementia.

Subjects
prevention   cognitive impairment   dementia   Alzheimer's disease   multidomain   lifestyle   intervention   randomized controlled trial   
URI
https://erepo.uef.fi/handle/123456789/6253
Link to the original item
http://dx.doi.org/10.1016/j.jalz.2017.09.006
Publisher
Elsevier BV
Collections
  • Terveystieteiden tiedekunta [1324]
University of Eastern Finland
OpenAccess
eRepo
erepo@uef.fi
OpenUEF
Service provided by
the University of Eastern Finland Library
Library web pages
Twitter
Facebook
Youtube
Library blog
 sitemap
Search

Browse

All of the ArchiveResource types & CollectionsBy Issue DateAuthorsTitlesSubjectsFacultyDepartmentFull organizationSeriesMain subjectThis CollectionBy Issue DateAuthorsTitlesSubjectsFacultyDepartmentFull organizationSeriesMain subject

My Account

Login
University of Eastern Finland
OpenAccess
eRepo
erepo@uef.fi
OpenUEF
Service provided by
the University of Eastern Finland Library
Library web pages
Twitter
Facebook
Youtube
Library blog
 sitemap