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dc.contributor.authorMarkl, Daniel
dc.contributor.authorWang, Parry
dc.contributor.authorRidgway, Cathy
dc.contributor.authorKarttunen, Anssi-Pekka
dc.contributor.authorBawuah, Prince
dc.contributor.authorKetolainen, Jarkko
dc.contributor.authorGane, Patrick
dc.contributor.authorPeiponen, Kai-Erik
dc.contributor.authorZeitler, J Axel
dc.date.accessioned2018-04-11T07:37:37Z
dc.date.available2018-04-11T07:37:37Z
dc.date.issued2018
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/6293
dc.description.abstractCost effectiveness, ease of use and patient compliance make pharmaceutical tablets the most popular and widespread form to administer a drug to a patient. Tablets typically consist of an active pharmaceutical ingredient and a selection from various excipients. A novel highly porous excipient, functionalised calcium carbonate (FCC), was designed to facilitate rapid liquid uptake leading to disintegration times of FCC based tablets in the matter of seconds. Five sets of FCC tablets with a target porosity of 45–65% in 5% steps were prepared and characterised using terahertz pulsed imaging (TPI). The high acquisition rate (15 Hz) of TPI enabled the analysis of the rapid liquid imbibition of water into these powder compacts. The penetration depth determined from the TPI measurements as a function of time was analysed by the power law and modelled for both the inertial (initial phase) and Lucas-Washburn (LW, longer time Laplace-​Poiseuillian) regimes. The analysis of the hydraulic radius estimated by fitting the liquid imbibition data to the LW equation demonstrates the impact of the porosity as well as the tortuosity of the pore channels on the liquid uptake performance. The tortuosity was related to the porosity by a geometrical model, which shows that the powder compact is constructed by aggregated particles with low permeability and its principal axis perpendicular to the compaction direction. The consideration of the tortuosity yielded a very high correlation (R2 = 0.96) between the porosity and the hydraulic pore radius. The terahertz data also resolved fluctuations (0.9–1.3 Hz) of the liquid movement which become more pronounced and higher in frequency with increasing porosity, which is attributed to the constrictivity of pore channels. This study highlights the strong impact of a tablet's microstructure on its liquid penetration kinetics and thus on its disintegration behaviour.
dc.language.isoenglanti
dc.publisherElsevier BV
dc.relation.ispartofseriesChemical Engineering Research And Design
dc.relation.urihttp://dx.doi.org/10.1016/j.cherd.2017.12.048
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/
dc.subjectporous media
dc.subjectpharmaceutical tablets
dc.subjectfunctionalised calcium carbonate
dc.subjectterahertz pulsed imaging
dc.subjectliquid imbibition
dc.subjectmodelling
dc.titleResolving the rapid water absorption of porous functionalised calcium carbonate powder compacts by terahertz pulsed imaging
dc.description.versionpublished version
dc.contributor.departmentSchool of Pharmacy, Activities
dc.contributor.departmentDepartment of Physics and Mathematics, activities
uef.solecris.id52164408en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Authors
dc.relation.doi10.1016/j.cherd.2017.12.048
dc.description.reviewstatuspeerReviewed
dc.format.pagerange1082-1090
dc.publisher.countryBritannia
dc.relation.issn0263-8762
dc.relation.volume132
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessHybridijulkaisukanavassa ilmestynyt avoin julkaisu


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