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dc.contributor.authorBelaya, Irina
dc.contributor.authorSuwa, Masataka
dc.contributor.authorChen, Tao
dc.contributor.authorGiniatullin, Rashid
dc.contributor.authorKanninen, Katja
dc.contributor.authorAtalay, Mustafa
dc.contributor.authorKumagai, Shuzo
dc.date.accessioned2018-04-11T07:58:19Z
dc.date.available2018-04-11T07:58:19Z
dc.date.issued2018
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/6295
dc.description.abstractThe current study examined the effect of aging and long-term wheel-running on the expression of heat shock protein (HSP), redox regulation, and endoplasmic reticulum (ER) stress markers in tibialis anterior (T.A.) and soleus muscle of mice. Male mice were divided into young (Y, 3-month-old), old-sedentary (OS, 24-month-old), and old-exercise (OE, 24-month-old) groups. The OE group started voluntary wheel-running at 3 months and continued until 24 months of age. Aging was associated with a higher thioredoxin-interacting protein (TxNiP) level, lower thioredoxin-1 (TRX-1) to TxNiP ratio—a determinant of redox regulation and increased CHOP, an indicator of ER stress-related apoptosis signaling in both muscles. Notably, GRP78, a key indicator of ER stress, was selectively elevated in T.A. Long-term exercise decreased TxNiP in T.A. and soleus muscles and increased the TRX-1/TxNiP ratio in soleus muscle of aged mice. Inducible HSP70 and constituent HSC70 were upregulated, whereas CHOP was reduced after exercise in soleus muscle. Thus, our data demonstrated that aging induced oxidative stress and activated ER stress-related apoptosis signaling in skeletal muscle, whereas long-term wheel-running improved redox regulation, ER stress adaptation and attenuated ER stress-related apoptosis signaling. These findings suggest that life-long exercise can protect against age-related cellular stress.
dc.language.isoEN
dc.publisherHindawi Limited
dc.relation.ispartofseriesOxidative Medicine and Cellular Longevity
dc.relation.urihttp://dx.doi.org/10.1155/2018/2894247
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/
dc.titleLong-term exercise protects against cellular stresses in aged mice
dc.description.versionpublished version
dc.contributor.departmentA.I. Virtanen -instituutti
dc.contributor.departmentSchool of Medicine / Biomedicine
uef.solecris.id52252148en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Authors
dc.relation.doi10.1155/2018/2894247
dc.description.reviewstatuspeerReviewed
dc.relation.articlenumber2894247
dc.relation.issn1942-0900
dc.relation.volume2018
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessOpen access -julkaisukanavassa ilmestynyt julkaisu


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