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dc.contributor.authorMäkelä, JT
dc.contributor.authorCooper, BG
dc.contributor.authorKorhonen, RK
dc.contributor.authorGrinstaff, MW
dc.contributor.authorSnyder, BD
dc.date.accessioned2018-04-13T12:14:49Z
dc.date.available2018-04-13T12:14:49Z
dc.date.issued2018
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/6319
dc.description.abstractObjective Depletion of glycosaminoglycans (GAGs) and degradation of collagen network are early hallmarks of osteoarthritis (OA). Currently, there are no chondroprotective therapies that mitigate the loss of GAGs or effectively restore the collagen network. Recently, a novel polymeric cartilage supplement was described that forms a charged interpenetrating polymer network (IPN) reconstituting the hydrophilic properties of the extracellular matrix (ECM). To investigate the mechanism by which this hydrophilic IPN improves articular cartilage material properties, a finite element (FE) model is used to evaluate the IPN's effect on the fibrillar collagen network, nonfibrillar matrix, and interstitial fluid flow. Methods Bovine osteochondral plugs were degraded with chondroitinase ABC to selectively decrease GAG content. Samples were mechanically tested before and after IPN treatment using unconfined testing geometry and stress-relaxation protocol. Every measurement was modeled separately using a fibril-reinforced poroviscoelastic FE model. Measurement replication was achieved by optimizing the following model parameters: initial and strain-dependent fibril network modulus (Ef0, Efε, respectively), nonfibrillar matrix modulus (Enf), initial permeability (k0) and strain-dependent permeability factor (M). Results Based on the FE model results, treatment of native and GAG depleted cartilage with the hydrophilic IPN increases the ECM stiffness and impedes fluid flow. The IPN did not alter the stiffness of fibrillary network. Cartilage permeability and the strain-dependent permeability factor decreased with increasing IPN w/v%. Conclusions The IPN reconstitutes cartilage material properties primarily by augmenting the hydrophilic ECM. This reinforcement of the solid phase also affects the fluid phase reestablishing low permeability.
dc.publisherElsevier BV
dc.relation.ispartofseriesOSTEOARTHRITIS AND CARTILAGE
dc.relation.urihttp://dx.doi.org/10.1016/j.joca.2018.01.001
dc.rightsCC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectarticular cartilage
dc.subjectosteoarthritis
dc.subjectbiomaterials
dc.subjectbiomechanics
dc.subjectfinite element analysis
dc.titleFunctional Effects of an Interpenetrating Polymer Network on Articular Cartilage Mechanical Properties
dc.description.versionfinal draft
dc.contributor.departmentDepartment of Applied Physics, activities
uef.solecris.id51951869en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Osteoarthritis Research Society International
dc.relation.doi10.1016/j.joca.2018.01.001
dc.description.reviewstatuspeerReviewed
dc.format.pagerange414-421
dc.relation.issn1063-4584
dc.relation.issue3
dc.relation.volume26
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessEi


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