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dc.contributor.authorMarkl, D
dc.contributor.authorStrobel, A
dc.contributor.authorSchlossnikl, R
dc.contributor.authorBøtker, J
dc.contributor.authorBawuah, P
dc.contributor.authorRidgway, C
dc.contributor.authorRantanen, J
dc.contributor.authorRades, T
dc.contributor.authorGane, P
dc.contributor.authorPeiponen, KE
dc.contributor.authorZeitler, JA
dc.date.accessioned2018-04-13T12:35:07Z
dc.date.available2018-04-13T12:35:07Z
dc.date.issued2018
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/6321
dc.description.abstractTraditionally, the development of a new solid dosage form is formulation-driven and less focus is put on the design of a specific microstructure for the drug delivery system. However, the compaction process particularly impacts the microstructure, or more precisely, the pore architecture in a pharmaceutical tablet. Besides the formulation, the pore structure is a major contributor to the overall performance of oral solid dosage forms as it directly affects the liquid uptake rate, which is the very first step of the dissolution process. In future, additive manufacturing is a potential game changer to design the inner structures and realise a tailor-made pore structure. In pharmaceutical development the pore structure is most commonly only described by the total porosity of the tablet matrix. Yet it is of great importance to consider other parameters to fully resolve the interplay between microstructure and dosage form performance. Specifically, tortuosity, connectivity, as well as pore shape, size and orientation all impact the flow paths and play an important role in describing the fluid flow in a pharmaceutical tablet. This review presents the key properties of the pore structures in solid dosage forms and it discusses how to measure these properties. In particular, the principles, advantages and limitations of helium pycnometry, mercury porosimetry, terahertz time-domain spectroscopy, nuclear magnetic resonance and X-ray computed microtomography are discussed.
dc.language.isoEN
dc.publisherElsevier BV
dc.relation.ispartofseriesINTERNATIONAL JOURNAL OF PHARMACEUTICS
dc.relation.urihttp://dx.doi.org/10.1016/j.ijpharm.2018.01.017
dc.rightsCC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectpore structure
dc.subjectsolid dosage form
dc.subjectterahertz technology
dc.subjectX-ray computed microtomography
dc.subjectmercury porosimetry
dc.subjecthelium pycnometry
dc.subjectnuclear magnetic resonance
dc.titleCharacterisation of Pore Structures of Pharmaceutical Tablets: A Review
dc.description.versionfinal draft
dc.contributor.departmentSchool of Pharmacy, Activities
dc.contributor.departmentDepartment of Physics and Mathematics, activities
uef.solecris.id52133064en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Elsevier B.V.
dc.relation.doi10.1016/j.ijpharm.2018.01.017
dc.description.reviewstatuspeerReviewed
dc.format.pagerange188-214
dc.publisher.countryAlankomaat
dc.relation.issn0378-5173
dc.relation.issue1-2
dc.relation.volume538
dc.rights.accesslevelopenAccess
dc.type.okmA2
uef.solecris.openaccessEi


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