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dc.contributor.authorVoutilainen, Markku
dc.contributor.authorHutri-Kähonen, Nina
dc.contributor.authorTossavainen, Päivi
dc.contributor.authorSipponen, Taina
dc.contributor.authorPitkänen, Niina
dc.contributor.authorLaitinen, Tomi
dc.contributor.authorJokinen, Eero
dc.contributor.authorRonnemaa, Tapani
dc.contributor.authorViikari, Jorma S A
dc.contributor.authorRaitakari, Olli T
dc.contributor.authorJuonala, Markus
dc.date.accessioned2018-04-25T11:12:38Z
dc.date.available2018-04-25T11:12:38Z
dc.date.issued2018
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/6550
dc.description.abstractBackground and aims Several genetic and environmental risk factors have been linked to chronic inflammatory bowel disease (IBD). The incidence of IBD has significantly increased in developed countries during last decades. The aim of the present study was to examine childhood risk factors for subsequent IBD diagnosis in a longitudinal cohort study of children and adolescents. Methods A Finnish study population consisting of 3551 children and adolescents originally evaluated as part of the Cardiovascular Risk in Young Finns study in 1980. At baseline, participant BMI, insulin, lipid, C-reactive protein and blood pressure levels, socioeconomic position, dietary habits, and physical activity, were evaluated. In addition, information was gathered on rural residency, severe infections, breast feeding, parental smoking and birth weight. Subsequent IBD diagnosis status was evaluated based on nationwide registries on hospitalisations and drug imbursement decisions. Results Altogether, 49 participants (1.4%) had IBD diagnosed during the 34 years of register follow-up, of which 31 had ulcerative colitis, 12 Crohn's disease and 6 undetermined colitis. In univariate analyses, significant correlations were observed between childhood HDL-cholesterol (risk ratio (95% CI) for 1-SD change (0.58 (0.42–0.79)) and CRP concentrations (1.20 (1.01–1.43)) with IBD. The inverse association between HDL-cholesterol and IBD remained significant (0.57 (0.39–0.82)) in a multivariable model including data on age, sex and CRP. In addition, a weighted genetic z-score of 71 single nucleotide polymorphisms associated with elevated HDL-cholesterol levels was significantly lower in IBD patients, P = 0.01). Conclusion Low childhood HDL-cholesterol levels are associated with subsequent IBD diagnosis. In addition, a genetic risk score associated with low HDL-cholesterol levels predict later IBD suggesting that HDL-cholesterol metabolism might have a role in the pathogenesis of IBD.
dc.language.isoEN
dc.publisherElsevier BV
dc.relation.ispartofseriesDIGESTIVE AND LIVER DISEASE
dc.relation.urihttp://dx.doi.org/10.1016/j.dld.2018.01.121
dc.rightsCC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectCrohn's disease
dc.subjectgenetics
dc.subjecthigh density lipoprotein cholesterol
dc.subjectinflammatory bowel disease
dc.subjectulcerative colitis
dc.titleLow childhood high density lipoprotein cholesterol levels and subsequent risk for chronic inflammatory bowel disease
dc.description.versionfinal draft
dc.contributor.departmentSchool of Medicine / Clinical Medicine
uef.solecris.id53932827en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Editrice Gastroenterologica Italiana S.r.l
dc.relation.doi10.1016/j.dld.2018.01.121
dc.description.reviewstatuspeerReviewed
dc.format.pagerange348-352
dc.relation.issn1590-8658
dc.relation.issue4
dc.relation.volume50
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessEi


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