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dc.contributor.authorTauriainen, Milla-Maria
dc.contributor.authorMännistö, Ville
dc.contributor.authorKaminska, Dorota
dc.contributor.authorVaittinen, Maija
dc.contributor.authorKärjä, Vesa
dc.contributor.authorKäkelä, Pirjo
dc.contributor.authorVenesmaa, Sari
dc.contributor.authorGylling, Helena
dc.contributor.authorPihlajamäki, Jussi
dc.date.accessioned2018-05-02T11:45:09Z
dc.date.available2018-05-02T11:45:09Z
dc.date.issued2018
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/6559
dc.description.abstractBackground and aims: Non-alcoholic fatty liver disease (NAFLD) associates with low levels of serum plant sterols in cross-sectional studies. In addition, it has been suggested that the hepatic sterol transport mechanisms are altered in NAFLD. Therefore, we investigated the association between serum, liver and bile plant sterols and sitostanol with NAFLD. Methods: Out of the 138 individuals (age: 46.3 +−8.9, body mass index: 43.3 +−6.9kg/m2, 28% men and 72% women), 44 could be histologically categorized to have normal liver, and 94 to have NAFLD. Within the NAFLD group, 28 had simple steatosis and 27 had non-alcoholic steatohepatitis. Plant sterols and sitostanol were measured from serum (n=138), liver (n=38), and bile (n=41). The mRNA expression of genes regulating liver sterol metabolism and inflammation was measured (n=102). Results: Liver and bile sitostanol ratios to cholesterol were higher in those with NAFLD compared to those with histologically normal liver (all P<0.022). Furthermore, liver sitostanol to cholesterol ratio correlated positively with histological steatosis and lobular inflammation (rs > 0.407, P<0.01 for both). In contrast, liver sitosterol to cholesterol ratio correlated negatively with steatosis (rs = −0.392, P=0.015) and lobular inflammation (rs = −0.395, P=0.014). Transcriptomics analysis revealed suggestive correlations between serum plant sterol levels and mRNA expression. Conclusion: Our study showed that liver and bile sitostanol ratios to cholesterol associated positively and liver sitosterol ratio to cholesterol associated negatively with liver steatosis and inflammation in obese individuals with NAFLD.
dc.publisherPortland Press Ltd.
dc.relation.ispartofseriesBioscience reports
dc.relation.urihttp://dx.doi.org/10.1042/BSR20171274
dc.titleSerum, liver and bile sitosterol and sitostanol in obese patients with and without NAFLD
dc.description.versionpublished version
dc.contributor.departmentSchool of Medicine / Clinical Nutrition
dc.contributor.departmentA.I. Virtanen -instituutti / Neurobiologia,School of Medicine / Clinical Medicine
uef.solecris.id53241198en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.relation.doi10.1042/BSR20171274
dc.description.reviewstatuspeerReviewed
dc.format.pagerange1-9
dc.relation.issn0144-8463
dc.relation.issue2
dc.relation.volume38
dc.type.okmA1
uef.solecris.openaccessOpen access -julkaisukanavassa ilmestynyt julkaisu


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