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dc.contributor.authorNykänen, O
dc.contributor.authorRieppo, L
dc.contributor.authorTöyräs, J
dc.contributor.authorKolehmainen, V
dc.contributor.authorSaarakkala, S
dc.contributor.authorShmueli, K
dc.contributor.authorNissi, MJ
dc.date.accessioned2018-05-04T08:38:52Z
dc.date.available2018-05-04T08:38:52Z
dc.date.issued2018
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/6568
dc.description.abstractPurpose We investigated the feasibility of quantitative susceptibility mapping (QSM) for assessing degradation of articular cartilage by measuring ex vivo bovine cartilage samples subjected to different degradative treatments. Specimens were scanned at several orientations to study if degradation affects the susceptibility anisotropy. T2*‐mapping, histological stainings, and polarized light microscopy were used as reference methods. Additionally, simulations of susceptibility in layered geometry were performed. Methods Samples (n = 9) were harvested from the patellae of skeletally mature bovines. Three specimens served as controls, and the rest were artificially degraded. MRI was performed at 9.4T using a 3D gradient echo sequence. QSM and T2* images and depth profiles through the centers of the samples were compared with each other and the histological findings. A planar isotropic model with depth‐wise susceptibility variation was used in the simulations. Results A strong diamagnetic contrast was seen in the deep and calcified layers of cartilage, while T2* maps reflected the typical trilaminar structure of the collagen network. Anisotropy of susceptibility in cartilage was observed and was found to differ from the T2* anisotropy. Slight changes were observed in QSM and T2* following the degradative treatments. In simulations, anisotropy was observed. Conclusions The results suggest that QSM is not sensitive to cartilage proteoglycan content, but shows sensitivity to the amount of calcification and to the integrity of the collagen network, providing potential for assessing osteoarthritis. The simulations suggested that the anisotropy of susceptibility might be partially explained by the layered geometry of susceptibility in cartilage.
dc.language.isoEN
dc.publisherWiley
dc.relation.ispartofseriesMAGNETIC RESONANCE IN MEDICINE
dc.relation.urihttp://dx.doi.org/10.1002/mrm.27216
dc.rightsCC BY-NC http://creativecommons.org/licenses/by-nc/4.0/
dc.titleQuantitative susceptibility mapping of articular cartilage: Ex vivo findings at multiple orientations and following different degradation treatments
dc.description.versionpublished version
dc.contributor.departmentDepartment of Applied Physics, activities
uef.solecris.id54192667en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Authors
dc.relation.doi10.1002/mrm.27216
dc.description.reviewstatuspeerReviewed
dc.relation.issn0740-3194
dc.relation.volumeFirst published: 24 April 2018
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessHybridijulkaisukanavassa ilmestynyt avoin julkaisu


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