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Birth size, body composition, and adrenal androgens as determinants of bone mineral density in mid-childhood

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Date
2018
Author(s)
Nordman, Henrikki
Voutilainen, Raimo
Laitinen, Tomi
Antikainen, Leena
Jääskeläinen, Jarmo
Unique identifier
10.1038/pr.2018.12
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Citation
Nordman, Henrikki. Voutilainen, Raimo. Laitinen, Tomi. Antikainen, Leena. Jääskeläinen, Jarmo. (2018). Birth size, body composition, and adrenal androgens as determinants of bone mineral density in mid-childhood.  PEDIATRIC RESEARCH, [Epub ahead of print 28 Feb 2018], 10.1038/pr.2018.12.
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Abstract

Background
Birth weight has an impact on adult bone mass. Higher birth weight is associated with greater bone mineral content (BMC) and children born small for gestational age (SGA) are at an increased risk for impaired accrual of bone mass. Our aim was to study whether the impact of birth size or early childhood growth on bone mass is visible already in mid-childhood.

Methods
We studied 49 children born large for gestational age (LGA), 56 children born appropriate for gestational age (AGA), and 23 children born SGA at 5.0–8.7 years of age. Body composition was assessed by whole-body dual-energy X-ray absorptiometry. Fasting blood samples and anthropometric data were collected.

Results
The children born SGA had lower bone mineral density (BMD) Z-score (P<0.001) and age- and sex-adjusted BMD (P<0.005) than the LGA and AGA children. Adjusted BMC, muscle mass, and body fat percentage (%BF) did not differ between the study groups. Muscle mass, BMI SD score (SDS), %BF, and serum dehydroepiandrosterone sulfate (DHEAS) concentration were the strongest predictors of high BMD in mid-childhood.

Conclusion
SGA-born children had lower BMD in mid-childhood compared with AGA- and LGA-born ones. Muscle mass or BMI SDS, %BF, and DHEAS were significant predictors of childhood BMD.

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https://erepo.uef.fi/handle/123456789/6583
Link to the original item
http://dx.doi.org/10.1038/pr.2018.12
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Springer Nature
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  • Terveystieteiden tiedekunta [1324]
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