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dc.contributor.authorSäisänen, Laura
dc.contributor.authorJulkunen, Petro
dc.contributor.authorLakka, Timo
dc.contributor.authorLindi, Virpi
dc.contributor.authorKönönen, Mervi
dc.contributor.authorMäättä
dc.contributor.authorSara
dc.date.accessioned2018-05-08T10:56:56Z
dc.date.available2018-05-08T10:56:56Z
dc.date.issued2018
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/6584
dc.description.abstractObjectives We characterized the maturation of the excitability of the motor cortex and corticospinal tract from childhood to adulthood using electric field (EF) navigated TMS and correlated the results with manual dexterity. Methods Both hemispheres of healthy right-handed children (6–9 years, n = 10), preadolescents (10–12 years, n = 13), adolescents (14–17 years, n = 12) and young adults (22–34 years, n = 12) of both genders were examined. The optimal cortical representation site and resting motor threshold (rMT) were determined for the abductor pollicis brevis muscle. Motor-evoked potential (MEP) latencies and amplitudes in relaxed and active states, input-output curves and silent period (SP) durations were determined. Manual dexterity was assessed with the Box and Block Test. Results rMT (in terms of maximal stimulator output or EF strength) decreased with age (P < 0.001) and stabilized when reaching adolescence. The MEP amplitude (P = 0.037) and latency increased (P < 0.001) with age. Input-output curves showed age-dependent changes in several parameters. SP duration decreased with age (P < 0.001), and demonstrated hemispheric asymmetry in the children (P = 0.030). Manual dexterity correlated negatively with rMT (P < 0.001). Discussion The excitation/inhibition balance develops with age and correlates with manual dexterity. Strong corticospinal inhibition was observed in the children and this was found to decrease with age. Interhemispheric asymmetry was only observed for SP duration in the children. Knowledge of normal development is crucial for the understanding of developmental disabilities and using estimates of effective EF may be advantageous in future pediatric studies.
dc.language.isoEN
dc.publisherElsevier BV
dc.relation.ispartofseriesNeurophysiologie Clinique
dc.relation.urihttp://dx.doi.org/10.1016/j.neucli.2017.11.004
dc.rightsCC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjecttranscranial magnetic stimulation
dc.subjecthuman maturation
dc.subjectdevelopment
dc.subjectmotor cortex
dc.subjectexcitability
dc.subjectsilent period
dc.titleDevelopment of corticospinal motor excitability and cortical silent period from mid-childhood to adulthood - a navigated TMS study
dc.description.versionpublished version
dc.contributor.departmentDepartment of Applied Physics, activities
dc.contributor.departmentSchool of Medicine / Biomedicine,School of Medicine / Clinical Medicine
uef.solecris.id51566409en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Elsevier Masson SAS
dc.relation.doi10.1016/j.neucli.2017.11.004
dc.description.reviewstatuspeerReviewed
dc.format.pagerange65-75
dc.relation.issn0987-7053
dc.relation.issue2
dc.relation.volume48
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessEi


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