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dc.contributor.authorKunutsor, SK
dc.contributor.authorSeidu, S
dc.contributor.authorKatechia, DT
dc.contributor.authorLaukkanen, JA
dc.date.accessioned2018-05-09T11:29:44Z
dc.date.available2018-05-09T11:29:44Z
dc.date.issued2018
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/6590
dc.description.abstractPurpose: We aimed to assess the prospective association of serum albumin with venous thromboembolism (VTE) risk and evaluate if the association is independent of or modified by inflammation, as measured by high sensitivity C-reactive protein (hsCRP). Design: We analysed data of 2176 men aged 42–61 years free from VTE in the Kuopio Ischemic Heart Disease study, with serum albumin concentrations measured at baseline using Coulter’s bromocresol purple colorimetric assays. Hazard ratios (HRs) (95% confidence intervals [CI]) were calculated for VTE. Results: There were 109 validated cases of VTE recorded during a median follow-up of 24.9 years. The risk of VTE increased linearly below a serum albumin concentration of ∼48 g/l. In Cox regression analysis adjusted for established risk factors and other potential confounders, the HR (95% CI) for VTE per 1 standard deviation lower serum albumin was 1.23 (1.02–1.47). The association remained persistent on further adjustment for hsCRP 1.22 (1.01–1.46). Furthermore, the association was not modified by hsCRP and persisted on exclusion of men with elevated hsCRP levels. Conclusions: In middle-aged Caucasian men, low serum albumin is associated with an increased risk of VTE, consistent with a linear dose-response relationship. The association is independent of and not modified by inflammation.
dc.language.isoEN
dc.publisherInforma UK Limited
dc.relation.ispartofseriesAnnals of Medicine
dc.relation.urihttp://dx.doi.org/10.1080/07853890.2018.1441537
dc.rightsAll rights reserved
dc.subjectserum albumin
dc.subjectvenous thromboembolism
dc.subjectinflammation
dc.subjectcohort study
dc.titleInverse association between serum albumin and future risk of venous thromboembolism: Interrelationship with high sensitivity C-reactive protein
dc.description.versionfinal draft
dc.contributor.departmentSchool of Medicine / Clinical Medicine
uef.solecris.id52723798en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Informa UK Limited, trading as Taylor & Francis Group
dc.relation.doi10.1080/07853890.2018.1441537
dc.description.reviewstatuspeerReviewed
dc.format.pagerange240-248
dc.publisher.countryBritannia
dc.relation.issn0785-3890
dc.relation.issue3
dc.relation.volume50
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessEi


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