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dc.contributor.authorLeimuranta, Pinja
dc.contributor.authorKhiroug, Leonard
dc.contributor.authorGiniatullin, Rashid
dc.date.accessioned2018-05-16T11:09:35Z
dc.date.available2018-05-16T11:09:35Z
dc.date.issued2018
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/6606
dc.description.abstractIn this mini-review, we summarize recent discoveries and present new hypotheses on the role of cannabinoids in controlling trigeminal nociceptive system underlying migraine pain. Individual sections of this review cover key aspects of this topic, such as: (i) the current knowledge on the endocannabinoid system (ECS) with emphasis on expression of its components in migraine related structures; (ii) distinguishing peripheral from central site of action of cannabinoids, (iii) proposed mechanisms of migraine pain and control of nociceptive traffic by cannabinoids at the level of meninges and in brainstem, (iv) therapeutic targeting in migraine of monoacylglycerol lipase and fatty acid amide hydrolase, enzymes which control the level of endocannabinoids; (v) dual (possibly opposing) actions of cannabinoids via anti-nociceptive CB1 and CB2 and pro-nociceptive TRPV1 receptors. We explore the cannabinoid-mediated mechanisms in the frame of the Clinical Endocannabinoid Deficiency (CECD) hypothesis, which implies reduced tone of endocannabinoids in migraine patients. We further discuss the control of cortical excitability by cannabinoids via inhibition of cortical spreading depression (CSD) underlying the migraine aura. Finally, we present our view on perspectives of Cannabis-derived (extracted or synthetized marijuana components) or novel endocannabinoid therapeutics in migraine treatment.
dc.language.isoenglanti
dc.publisherFrontiers Media SA
dc.relation.ispartofseriesFRONTIERS IN PHARMACOLOGY
dc.relation.urihttp://dx.doi.org/10.3389/fphar.2018.00420
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/
dc.subjectmigraine
dc.subjectcannabinoids
dc.subjectCGRP
dc.subjectnociception
dc.subjectmarijuana
dc.subjectcannabinoid receptor
dc.subjectTRPV1
dc.titleEmerging Role of (Endo)Cannabinoids in Migraine
dc.description.versionpublished version
dc.contributor.departmentA.I. Virtanen -instituutti
uef.solecris.id54424260en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Authors
dc.relation.doi10.3389/fphar.2018.00420
dc.description.reviewstatuspeerReviewed
dc.relation.articlenumber420
dc.relation.issn1663-9812
dc.relation.volume9
dc.rights.accesslevelopenAccess
dc.type.okmA2
uef.solecris.openaccessOpen access -julkaisukanavassa ilmestynyt julkaisu


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