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Assessment of genotoxicity and genomic instability in rat primary astrocytes exposed to 872 MHz radiofrequency radiation and chemicals.

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Date
2018
Author(s)
Herrala, Mikko
Mustafa, Ehab
Naarala, Jonne
Juutilainen, Jukka
Unique identifier
10.1080/09553002.2018.1450534
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Citation
Herrala, Mikko. Mustafa, Ehab. Naarala, Jonne. Juutilainen, Jukka. (2018). Assessment of genotoxicity and genomic instability in rat primary astrocytes exposed to 872 MHz radiofrequency radiation and chemicals..  INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, [Published online 23 Mar 2018], 10.1080/09553002.2018.1450534.
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Abstract

Purpose: We examined genotoxicity, co-genotoxicity and induced genomic instability (IGI) in primary astrocytes exposed to radiofrequency (RF) radiation.

Materials and methods: Rat primary astrocytes were exposed to 872 MHz GSM-modulated or continuous wave (CW) RF radiation at specific absorption rates of 0.6 or 6.0 W/kg for 24 h. Menadione (MQ) and methyl methanesulfonate (MMS; only in genotoxicity experiments) were used as co-exposures. Alkaline Comet assay and flow cytometric micronucleus scoring were used to detect genetic damage.

Results: No IGI was observed from RF radiation alone or combined treatment with MQ. RF radiation alone was not genotoxic. RF radiation combined with chemical exposure showed some statistically significant differences: increased DNA damage at 6.0 W/kg but decreased DNA damage at 0.6 W/kg in cells exposed to GSM-modulated RF radiation and MQ, and increased micronucleus frequency in cells exposed to CW RF radiation at 0.6 W/kg and MMS.

Conclusions: Exposure to GSM modulated RF radiation at levels up to 6.0 W/kg did not induce or enhance genomic instability in rat primary astrocytes. Lack of genotoxicity from RF radiation alone was convincingly shown in multiple experiments. Co-genotoxicity of RF radiation and genotoxic chemicals was not consistently supported by the results.

Subjects
radiofrequency   mobile phone radiation   genotoxicity   co-genotoxicity   genomic instability   
URI
https://erepo.uef.fi/handle/123456789/6625
Link to the original item
http://dx.doi.org/10.1080/09553002.2018.1450534
Publisher
Informa UK Limited
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  • Luonnontieteiden ja metsätieteiden tiedekunta [1144]
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