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dc.contributor.authorBawuah, Prince
dc.contributor.authorKarttunen, Anssi-Pekka
dc.contributor.authorMarkl, Daniel
dc.contributor.authorRidgway, Cathy
dc.contributor.authorKorhonen, Ossi
dc.contributor.authorGane, Patrick
dc.contributor.authorZeitler, J Axel
dc.contributor.authorKetolainen, Jarkko
dc.contributor.authorPeiponen, Kai-Erik
dc.date.accessioned2018-05-18T10:11:58Z
dc.date.available2018-05-18T10:11:58Z
dc.date.issued2018
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/6631
dc.description.abstractHeckel analysis is a widely used method for the characterisation of the compression behaviour of pharmaceutical samples during the preparation of solid dosage formulations. The present study introduces an optical version of the Heckel equation that is based on a combination of the conventional Heckel equation together with the linear relationship defined between the effective terahertz (THz) refractive index and the porosity of pharmaceutical tablets. The proposed optical Heckel equation allows us to, firstly, calculate the zero-porosity refractive index, and, secondly, predict the in-die development of the effective refractive index as a function of the compressive pressure during tablet compression. This was demonstrated for five batches of highly porous functionalised calcium carbonate (FCC) excipient compacts. The close match observed between the estimated in-die effective refractive index and the measured/out-of-die effective THz refractive index supports the validity of the proposed form of the equation. By comparing the measured and estimated in-die tablet properties, a clear change in the porosity and hence, the effective refractive index, due to post-compression elastic relaxation of the FCC compacts, has been observed. We have, therefore, proposed a THz-based compaction setup that will permit in-line monitoring of processes during tablet compression. We envisage that this new approach in tracking powder properties introduced in this preliminary study will lead to the onset of further extensive and detailed future studies.
dc.language.isoenglanti
dc.publisherElsevier BV
dc.relation.ispartofseriesINTERNATIONAL JOURNAL OF PHARMACEUTICS
dc.relation.urihttp://dx.doi.org/10.1016/j.ijpharm.2018.04.043
dc.rightsCC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectHeckel law
dc.subjectpharmaceutical tablet
dc.subjectelastic relaxation
dc.subjectporosity
dc.subjectterahertz refractive index
dc.titleInvestigating elastic relaxation effects on the optical properties of functionalised calcium carbonate compacts using optics-based Heckel analysis
dc.description.versionfinal draft
dc.contributor.departmentSchool of Pharmacy, Activities
dc.contributor.departmentDepartment of Physics and Mathematics, activities
uef.solecris.id54076975en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Elsevier B.V.
dc.relation.doi10.1016/j.ijpharm.2018.04.043
dc.description.reviewstatuspeerReviewed
dc.format.pagerange278-284
dc.publisher.countryAlankomaat
dc.relation.issn0378-5173
dc.relation.issue1
dc.relation.volume544
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessEi


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