Show simple item record

dc.contributor.authorBhattarai, A
dc.contributor.authorHonkanen, JTJ
dc.contributor.authorMyller, KAH
dc.contributor.authorPrakash, M
dc.contributor.authorKorhonen M
dc.contributor.authorSaukko, AEA
dc.contributor.authorVirén, T
dc.contributor.authorJoukainen, A
dc.contributor.authorPatwa, AN
dc.contributor.authorKröger, H
dc.contributor.authorGrinstaf, MW
dc.contributor.authorJurvelin, JS
dc.contributor.authorTöyräs, J;
dc.date.accessioned2018-08-13T08:05:12Z
dc.date.available2018-08-13T08:05:12Z
dc.date.issued2018
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/6766
dc.description.abstractImpact injuries of cartilage may initiate post-traumatic degeneration, making early detection of injury imperative for timely surgical or pharmaceutical interventions. Cationic (positively-charged) CT contrast agents detect loss of cartilage proteoglycans (PGs) more sensitively than anionic (negatively-charged) or non-ionic (non-charged, i.e., electrically neutral) agents. However, degeneration related loss of PGs and increase in water content have opposite effects on the diffusion of the cationic agent, lowering its sensitivity. In contrast to cationic agents, diffusion of non-ionic agents is governed only by steric hindrance and water content of cartilage. We hypothesize that sensitivity of an iodine(I)-based cationic agent may be enhanced by simultaneous use of a non-ionic gadolinium(Gd)-based agent. We introduce a quantitative dual energy CT technique (QDECT) for simultaneous quantification of two contrast agents in cartilage. We employ this technique to improve the sensitivity of cationic CA4+ (q =+4) by normalizing its partition in cartilage with that of non-ionic gadoteridol. The technique was evaluated with measurements of contrast agent mixtures of known composition and human osteochondral samples (n = 57) after immersion (72 h) in mixture of CA4+ and gadoteridol. Samples were arthroscopically graded and biomechanically tested prior to QDECT (50/100 kV). QDECT determined contrast agent mixture compositions correlated with the true compositions (R2= 0.99, average error = 2.27%). Normalizing CA4+ partition in cartilage with that of gadoteridol improved correlation with equilibrium modulus (from ρ = 0.701 to 0.795). To conclude, QDECT enables simultaneous quantification of I and Gd contrast agents improving diagnosis of cartilage integrity and biomechanical status.
dc.language.isoenglanti
dc.publisherSpringer Nature
dc.relation.ispartofseriesANNALS OF BIOMEDICAL ENGINEERING
dc.relation.urihttp://dx.doi.org/10.1007/s10439-018-2013-y
dc.rightsAll rights reserved
dc.subjectbiomechanics
dc.subjectcartilage
dc.subjectcationic contrast agent
dc.subjectcontrast enhanced computed tomography
dc.subjectdual energy CT
dc.titleQuantitative Dual Contrast CT Technique for Evaluation of Articular Cartilage Properties
dc.description.versionfinal draft
dc.contributor.departmentDepartment of Applied Physics, activities
dc.contributor.departmentFaculty of Science and Forestry, shared activities,Department of Physics and Mathematics, activities,School of Medicine / Clinical Medicine
uef.solecris.id53846974en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Biomedical Engineering Society
dc.relation.doi10.1007/s10439-018-2013-y
dc.description.reviewstatuspeerReviewed
dc.format.pagerange1038–1046
dc.relation.issn0090-6964
dc.relation.issue7
dc.relation.volume46
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessEi


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record