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dc.contributor.authorMøller, P
dc.contributor.authorSeppälä, TT
dc.contributor.authorBernstein, I
dc.contributor.authorHolinski-Feder, E
dc.contributor.authorSala, P
dc.contributor.authorGareth Evans, D
dc.contributor.authorLindblom, A
dc.contributor.authorMacrae, F
dc.contributor.authorBlanco, I
dc.contributor.authorSijmons, RH
dc.contributor.authorJeffries, J
dc.contributor.authorVasen, HFA
dc.contributor.authorBurn, J
dc.contributor.authorNakken, S
dc.contributor.authorHovig, E
dc.contributor.authorRødland, EA
dc.contributor.authorTharmaratnam, K
dc.contributor.authorde Vos Tot, Nederveen Cappel, WH
dc.contributor.authorHill, J
dc.contributor.authoret al [Incl Mecklin, J-P] in collaboration with The Mallorca Group
dc.date.accessioned2018-08-13T08:20:01Z
dc.date.available2018-08-13T08:20:01Z
dc.date.issued2018
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/6768
dc.description.abstractBackground Most patients with path_MMR gene variants (Lynch syndrome (LS)) now survive both their first and subsequent cancers, resulting in a growing number of older patients with LS for whom limited information exists with respect to cancer risk and survival. Objective and design This observational, international, multicentre study aimed to determine prospectively observed incidences of cancers and survival in path_MMR carriers up to 75 years of age. Results 3119 patients were followed for a total of 24 475 years. Cumulative incidences at 75 years (risks) for colorectal cancer were 46%, 43% and 15% in path_MLH1, path_MSH2 and path_MSH6 carriers; for endometrial cancer 43%, 57% and 46%; for ovarian cancer 10%, 17% and 13%; for upper gastrointestinal (gastric, duodenal, bile duct or pancreatic) cancers 21%, 10% and 7%; for urinary tract cancers 8%, 25% and 11%; for prostate cancer 17%, 32% and 18%; and for brain tumours 1%, 5% and 1%, respectively. Ovarian cancer occurred mainly premenopausally. By contrast, upper gastrointestinal, urinary tract and prostate cancers occurred predominantly at older ages. Overall 5-year survival for prostate cancer was 100%, urinary bladder 93%, ureter 85%, duodenum 67%, stomach 61%, bile duct 29%, brain 22% and pancreas 0%. Path_PMS2 carriers had lower risk for cancer. Conclusion Carriers of different path_MMR variants exhibit distinct patterns of cancer risk and survival as they age. Risk estimates for counselling and planning of surveillance and treatment should be tailored to each patient’s age, gender and path_MMR variant. We have updated our open-access website www.lscarisk.org to facilitate this.
dc.language.isoenglanti
dc.publisherBMJ
dc.relation.ispartofseriesGUT
dc.relation.urihttp://dx.doi.org/10.1136/gutjnl-2017-314057
dc.rightsCC BY-NC http://creativecommons.org/licenses/by-nc/4.0/
dc.titleCancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database .
dc.description.versionpublished version
dc.contributor.departmentSchool of Medicine / Clinical Medicine
uef.solecris.id56047240en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Authors
dc.relation.doi10.1136/gutjnl-2017-314057
dc.description.reviewstatuspeerReviewed
dc.format.pagerange1303-1316
dc.relation.issn0017-5749
dc.relation.issue7
dc.relation.volume67
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessHybridijulkaisukanavassa ilmestynyt avoin julkaisu


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