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dc.contributor.authorObey, JK
dc.contributor.authorNgeiywa, MM
dc.contributor.authorKiprono, P
dc.contributor.authorOmar, S
dc.contributor.authorvon Wright, A
dc.contributor.authorKauhanen, J
dc.contributor.authorTikkanen-Kaukanen, C
dc.date.accessioned2018-08-14T12:15:13Z
dc.date.available2018-08-14T12:15:13Z
dc.date.issued2018
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/6796
dc.description.abstractThere is an increasing need for innovative drug and prophylaxis discovery againstmalaria. The aim of the present study was to test in vivo antiplasmodial activity of Croton macrostachyus H. (Euphorbiaceae) stem bark extracts from Kenyan folkloric medicine. Inbred Balb/c mice were inoculated with erythrocytes parasitized with Plasmodium berghei (ANKA). Different doses (500, 250, and 100mg/kg) of C. macrostachyus ethyl acetate, methanol, aqueous, and isobutanol extracts were administrated either after inoculation (Peters’ 4-day suppressive test) or before inoculation (chemoprotective test) of the parasitized erythrocytes. All the extracts showed significant suppression of parasitemia compared to control (𝑝 < 0.001): for the ethyl acetate extract in the range of 58–82%, for themethanol extract in the range of 27–68%, for the aqueous extract in the range of 24–72%, and for the isobutanol extract in the range of 61–80%. Chemoprotective effect was significant (𝑝 < 0.001) and the suppression caused by the ethyl acetate extract was between 74 and 100%, by themethanol extract between 57 and 83%, and by the isobutanol extract between 86–92%.The study showed that it is possible to inhibit the growth of the parasites by various stem bark extracts of C. macrostachyus in Balb/c mice supporting the folkloric use of the plant against malaria.
dc.language.isoenglanti
dc.publisherHindawi Limited
dc.relation.ispartofseriesJournal of Pathogens
dc.relation.urihttp://dx.doi.org/10.1155/2018/2393854
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/
dc.titleAntimalarial Activity of Croton macrostachyus Stem Bark Extracts against Plasmodium berghei In Vivo
dc.description.versionpublished version
dc.contributor.departmentSchool of Medicine / Public Health
uef.solecris.id55844200en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Authors
dc.relation.doi10.1155/2018/2393854
dc.description.reviewstatuspeerReviewed
dc.format.pagerange2393854
dc.publisher.countryEgypti
dc.relation.issn2090-3057
dc.relation.volume2018
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessOpen access -julkaisukanavassa ilmestynyt julkaisu


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