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dc.contributor.authorVellonen, Kati-Sisko
dc.contributor.authorHellinen, Laura
dc.contributor.authorMannermaa, Eliisa
dc.contributor.authorRuponen, Marika
dc.contributor.authorUrtti, Arto
dc.contributor.authorKidron, Heidi
dc.date.accessioned2018-08-17T06:37:19Z
dc.date.available2018-08-17T06:37:19Z
dc.date.issued2018
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/6803
dc.description.abstractThe eye is protected by several tissues that limit the permeability and entry of potentially harmful substances, but also hamper the delivery of drugs in the treatment of ocular diseases. Active transport across the ocular barriers may affect drug distribution, but the impact of drug transporters on ocular drug delivery is not well known. We have collected and critically reviewed the literature for ocular expression and activity of known drug transporters. The review concentrates on drug transporters that have been functionally characterized in ocular tissues or primary cells and on transporters for which there is available expression data at the protein level. Species differences are highlighted, since these may explain observed inconsistencies in the influence of specific transporters on drug disposition. There is variable evidence about the pharmacokinetic role of transporters in ocular tissues. The strongest evidence for the role of active transport is available for the blood-retinal barrier. We explored the role of active transport in the cornea and blood retinal barrier with pharmacokinetic simulations. The simulations show that the active transport is important only in the case of specific parameter combinations.
dc.language.isoenglanti
dc.publisherElsevier BV
dc.relation.ispartofseriesADVANCED DRUG DELIVERY REVIEWS
dc.relation.urihttp://dx.doi.org/10.1016/j.addr.2017.12.009
dc.rightsCC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectactive transport
dc.subjectblood-retinal barrier
dc.subjectblood-aqueous barrier
dc.subjectconjunctiva
dc.subjectcornea
dc.subjectneural retina
dc.subjectpharmacogenetics
dc.titleExpression, activity and pharmacokinetic impact of ocular transporters
dc.description.versionfinal draft
dc.contributor.departmentSchool of Pharmacy, Activities
uef.solecris.id51567125en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Elsevier B.V.
dc.relation.doi10.1016/j.addr.2017.12.009
dc.description.reviewstatuspeerReviewed
dc.format.pagerange3-22
dc.publisher.countryAlankomaat
dc.relation.issn0169-409X
dc.relation.volume126
dc.rights.accesslevelopenAccess
dc.type.okmA2
uef.solecris.openaccessEi


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