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dc.contributor.authorSilvola, JMU
dc.contributor.authorLi, XG
dc.contributor.authorVirta, J
dc.contributor.authorMarjamäki, P
dc.contributor.authorLiljenbäck, H
dc.contributor.authorHytönen, JP
dc.contributor.authorTarkia, M
dc.contributor.authorSaunavaara, V
dc.contributor.authorHurme, S
dc.contributor.authorPalani, S
dc.contributor.authorHakovirta, H
dc.contributor.authorYlä-Herttuala, S
dc.contributor.authorSaukko, P
dc.contributor.authorChen, Q
dc.contributor.authorLow, PS
dc.contributor.authorKnuuti, J
dc.contributor.authorSaraste, A
dc.contributor.authorRoivainen, A
dc.date.accessioned2018-08-17T11:39:47Z
dc.date.available2018-08-17T11:39:47Z
dc.date.issued2018
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/6814
dc.description.abstractInflammation plays an important role in the development of atherosclerosis and its complications. Because the folate receptor β (FR-β) is selectively expressed on macrophages, an FR targeted imaging agent could be useful for assessment of atherosclerotic inflammation. We investigated aluminum fluoride-18-labeled 1,4,7-triazacyclononane-1,4,7-triacetic acid conjugated folate (18F-FOL) for the detection of atherosclerotic plaque inflammation. We studied atherosclerotic plaques in mice, rabbits, and human tissue samples using 18F-FOL positron emission tomography/computed tomography (PET/CT). Compound 2-deoxy-2-[18F]fluoro-D-glucose (18F-FDG) was used as a comparison. Firstly, we found that the in vitro binding of 18F-FOL co-localized with FR-β-positive macrophages in carotid endarterectomy samples from patients with recent ischemic symptoms. We then demonstrated specific accumulation of intravenously administered 18F-FOL in atherosclerotic plaques in mice and rabbits using PET/CT. We noticed that the 18F-FOL uptake correlated with the density of macrophages in plaques and provided a target-to-background ratio as high as 18F-FDG, but with considerably lower myocardial uptake. Thus, 18F-FOL PET/CT targeting of FR-β-positive macrophages presents a promising new tool for the in vivo imaging of atherosclerotic inflammation.
dc.language.isoenglanti
dc.publisherSpringer Nature
dc.relation.ispartofseriesScientific Reports
dc.relation.urihttp://dx.doi.org/10.1038/s41598-018-27618-4
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/
dc.titleAluminum fluoride-18 labeled folate enables in vivo detection of atherosclerotic plaque inflammation by positron emission tomography
dc.description.versionpublished version
dc.contributor.departmentA.I. Virtanen -instituutti
uef.solecris.id55580035en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Authors
dc.relation.doi10.1038/s41598-018-27618-4
dc.description.reviewstatuspeerReviewed
dc.relation.articlenumber9720
dc.relation.issn2045-2322
dc.relation.issue1
dc.relation.volume8
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessOpen access -julkaisukanavassa ilmestynyt julkaisu


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