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dc.contributor.authorXu, Wujun
dc.contributor.authorTamarov, Konstantin
dc.contributor.authorFan, Li
dc.contributor.authorGranroth, Sari
dc.contributor.authorRantanen, Jimi
dc.contributor.authorNissinen, Tuomo
dc.contributor.authorPeraniemi, Sirpa
dc.contributor.authorUski, Oskari
dc.contributor.authorHirvonen, Maija-Riitta
dc.contributor.authorLehto, Vesa-Pekka
dc.date.accessioned2018-08-28T08:13:12Z
dc.date.available2018-08-28T08:13:12Z
dc.date.issued2018
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/6855
dc.description.abstractPorous silicon (PSi) has attracted wide interest as a potential material for various fields of nanomedicine. However, until now, the application of PSi in photothermal therapy has not been successful due to its low photothermal conversion efficiency. In the present study, biodegradable black PSi (BPSi) nanoparticles were designed and prepared via a high-yield and simple reaction. The PSi nanoparticles possessed a low band gap of 1.34 eV, a high extinction coefficient of 13.2 L/g/cm at 808 nm, a high photothermal conversion efficiency of 33.6%, good photostability, and a large surface area. The nanoparticles had not only excellent photothermal properties surpassing most of the present inorganic photothermal conversion agents (PCAs) but they also displayed good biodegradability, a common problem encountered with the inorganic PCAs. The functionality of the BPSi nanoparticles in photothermal therapy was verified in tumor-bearing mice in vivo. These results showed clearly that the photothermal treatment was highly efficient to inhibit tumor growth. The designed PCA material of BPSi is robust, easy to prepare, biocompatible, and therapeutically extremely efficient and it can be integrated with several other functionalities on the basis of simple silicon chemistry.
dc.language.isoenglanti
dc.publisherAmerican Chemical Society (ACS)
dc.relation.ispartofseriesACS Applied Materials & Interfaces
dc.relation.urihttp://dx.doi.org/10.1021/acsami.8b04557
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/
dc.subjectbiodegradability
dc.subjectcancer therapy
dc.subjecthigh yield
dc.subjectphotothermal treatment
dc.subjectporous silicon
dc.titleScalable Synthesis of Biodegradable Black Mesoporous Silicon Nanoparticles for Highly Efficient Photothermal Therapy
dc.description.versionpublished version
dc.contributor.departmentDepartment of Applied Physics, activities
uef.solecris.id56452972en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© American Chemical Society
dc.relation.doi10.1021/acsami.8b04557
dc.description.reviewstatuspeerReviewed
dc.format.pagerange23529-23538
dc.relation.issn1944-8244
dc.relation.issue28
dc.relation.volume10
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessEi


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