dc.contributor.author | Hakkarainen, Heidi | |
dc.contributor.author | Huopio, Hanna | |
dc.contributor.author | Cederberg, Henna | |
dc.contributor.author | Voutilainen, Raimo | |
dc.contributor.author | Heinonen, Seppo | |
dc.date.accessioned | 2018-08-31T11:30:51Z | |
dc.date.available | 2018-08-31T11:30:51Z | |
dc.date.issued | 2018 | |
dc.identifier.uri | https://erepo.uef.fi/handle/123456789/6890 | |
dc.description.abstract | Background
Whether the delivery of a large-for-gestational-age (LGA) infant predicts future maternal metabolic syndrome (MetS) is not known. To this aim, we investigated the incidence of MetS and its components in women with or without a history of gestational diabetes mellitus (GDM) with a view to the birth weight of the offspring.
Methods
Eight hundred seventy six women treated for their pregnancies in Kuopio University Hospital in 1989–2009 underwent a follow-up study (mean follow-up time 7.3 (SD 5.1) years), of whom 489 women with GDM and 385 normoglycemic controls. The women were stratified into two groups according to the newborn’s birth weight: 10-90th percentile (appropriate-for-gestational-age; AGA) (n = 662) and > 90th percentile (LGA) (n = 116). MetS and its components were evaluated in the follow-up study according to the International Diabetes Federation criteria.
Results
LGA vs. AGA delivery was associated with a higher incidence of MetS at follow-up in women with a background of GDM (54.4% vs. 43.6%), but not in women without GDM.
Conclusion
An LGA delivery in women with GDM is associated with a higher risk of future MetS and this group is optimal to study preventive measures for MetS. In contrast, an LGA delivery after a normoglycemic pregnancy was not associated with an increased future maternal MetS risk. | |
dc.language.iso | englanti | |
dc.publisher | Springer Nature America, Inc | |
dc.relation.ispartofseries | Bmc pregnancy and childbirth | |
dc.relation.uri | http://dx.doi.org/10.1186/s12884-018-1958-z | |
dc.rights | CC BY http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | gestational diabetes mellitus | |
dc.subject | metabolic syndrome | |
dc.subject | large-for-gestational-age | |
dc.subject | birth weight | |
dc.title | Future risk of metabolic syndrome in women with a previous LGA delivery stratified by gestational glucose tolerance: a prospective cohort study | |
dc.description.version | published version | |
dc.contributor.department | School of Medicine / Clinical Medicine | |
uef.solecris.id | 56716426 | en |
dc.type.publication | Tieteelliset aikakauslehtiartikkelit | |
dc.rights.accessrights | © Authors | |
dc.relation.doi | 10.1186/s12884-018-1958-z | |
dc.description.reviewstatus | peerReviewed | |
dc.relation.articlenumber | 326 | |
dc.relation.volume | 18 | |
dc.rights.accesslevel | openAccess | |
dc.type.okm | A1 | |
uef.solecris.openaccess | Open access -julkaisukanavassa ilmestynyt julkaisu | |