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dc.contributor.authorHakkarainen, Heidi
dc.contributor.authorHuopio, Hanna
dc.contributor.authorCederberg, Henna
dc.contributor.authorVoutilainen, Raimo
dc.contributor.authorHeinonen, Seppo
dc.date.accessioned2018-08-31T11:30:51Z
dc.date.available2018-08-31T11:30:51Z
dc.date.issued2018
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/6890
dc.description.abstractBackground Whether the delivery of a large-for-gestational-age (LGA) infant predicts future maternal metabolic syndrome (MetS) is not known. To this aim, we investigated the incidence of MetS and its components in women with or without a history of gestational diabetes mellitus (GDM) with a view to the birth weight of the offspring. Methods Eight hundred seventy six women treated for their pregnancies in Kuopio University Hospital in 1989–2009 underwent a follow-up study (mean follow-up time 7.3 (SD 5.1) years), of whom 489 women with GDM and 385 normoglycemic controls. The women were stratified into two groups according to the newborn’s birth weight: 10-90th percentile (appropriate-for-gestational-age; AGA) (n = 662) and > 90th percentile (LGA) (n = 116). MetS and its components were evaluated in the follow-up study according to the International Diabetes Federation criteria. Results LGA vs. AGA delivery was associated with a higher incidence of MetS at follow-up in women with a background of GDM (54.4% vs. 43.6%), but not in women without GDM. Conclusion An LGA delivery in women with GDM is associated with a higher risk of future MetS and this group is optimal to study preventive measures for MetS. In contrast, an LGA delivery after a normoglycemic pregnancy was not associated with an increased future maternal MetS risk.
dc.language.isoenglanti
dc.publisherSpringer Nature America, Inc
dc.relation.ispartofseriesBmc pregnancy and childbirth
dc.relation.urihttp://dx.doi.org/10.1186/s12884-018-1958-z
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/
dc.subjectgestational diabetes mellitus
dc.subjectmetabolic syndrome
dc.subjectlarge-for-gestational-age
dc.subjectbirth weight
dc.titleFuture risk of metabolic syndrome in women with a previous LGA delivery stratified by gestational glucose tolerance: a prospective cohort study
dc.description.versionpublished version
dc.contributor.departmentSchool of Medicine / Clinical Medicine
uef.solecris.id56716426en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Authors
dc.relation.doi10.1186/s12884-018-1958-z
dc.description.reviewstatuspeerReviewed
dc.relation.articlenumber326
dc.relation.volume18
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessOpen access -julkaisukanavassa ilmestynyt julkaisu


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