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dc.contributor.authorSaari, T
dc.contributor.authorHallikainen, I
dc.contributor.authorHänninen, T
dc.contributor.authorRäty, H
dc.contributor.authorKoivisto, A
dc.date.accessioned2018-09-13T09:52:08Z
dc.date.available2018-09-13T09:52:08Z
dc.date.issued2018
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/6908
dc.description.abstractBackground: Impaired cognition and activities of daily living (ADL) are core symptoms of Alzheimer’s disease (AD), but their relationship is unclear. Objectives: To explore relationships between cognitive domains and functional ability during 5-year follow-up in persons with AD. Methods: We analyzed ALSOVA study data from 236 individuals with very mild or mild AD at baseline. The CERAD Neuropsychological Battery (CERAD-NB) was used as a cognitive measure and Alzheimer’s Disease Cooperative Study ADL (ADCS-ADL) as a functional measure, analyzing the IADL and BADL sub-scores separately. Annual regression models and linear mixed-effect models (LMMs) covering a 5-year follow-up period were used. Results: Annually, the CERAD-NB total and especially Verbal Fluency, Clock Drawing, and Constructional Praxis were associated with the total ADCS-ADL and IADL scores increasingly yet modestly, and to a lesser extent the BADL score. In the LMMs, the same measures and MMSE were associated with ADL. Conclusion: Measures of executive function and visuoconstructive skills appear to be associated with caregiver-interview based ADL measure during the progression of AD.
dc.language.isoenglanti
dc.publisherIOS Press
dc.relation.ispartofseriesJournal of Alzheimer's Disease
dc.relation.urihttp://dx.doi.org/10.3233/JAD-171059
dc.rightsAll rights reserved
dc.titleRelationships between Cognition and Activities of Daily Living in Alzheimer's Disease During a 5-Year Follow-Up: ALSOVA Study
dc.description.versionfinal draft
dc.contributor.departmentSchool of Medicine / Clinical Medicine
dc.contributor.departmentSchool of Educational Sciences and Psychology / Psychology
uef.solecris.id55096185en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© IOS Press and the authors
dc.relation.doi10.3233/JAD-171059
dc.description.reviewstatuspeerReviewed
dc.format.pagerange269-279
dc.publisher.countryAlankomaat
dc.relation.issn1387-2877
dc.relation.issue1
dc.relation.volume64
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessEi


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