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dc.contributor.authorCaporali, A
dc.contributor.authorBäck, M
dc.contributor.authorDaemen, MJ
dc.contributor.authorHoefer, IE
dc.contributor.authorJones, EA
dc.contributor.authorLutgens, E
dc.contributor.authorMatter, CM
dc.contributor.authorBochaton-Piallat, ML
dc.contributor.authorSiekmann, AF
dc.contributor.authorSluimer, JC
dc.contributor.authorSteffens, S
dc.contributor.authorTuñón, J
dc.contributor.authorVindis, C
dc.contributor.authorWentzel, JJ
dc.contributor.authorYlä-Herttuala, S
dc.contributor.authorEvans, PC
dc.date.accessioned2018-09-21T11:56:48Z
dc.date.available2018-09-21T11:56:48Z
dc.date.issued2018
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/6937
dc.description.abstractModulation of vessel growth holds great promise for treatment of cardiovascular disease. Strategies to promote vascularization can potentially restore function in ischaemic tissues. On the other hand, plaque neovascularization has been shown to associate with vulnerable plaque phenotypes and adverse events. The current lack of clinical success in regulating vascularization illustrates the complexity of the vascularization process, which involves a delicate balance between pro- and antiangiogenic regulators and effectors. This is compounded by limitations in the models used to study vascularization that do not reflect the eventual clinical target population. Nevertheless, there is a large body of evidence that validate the importance of angiogenesis as a therapeutic concept. The overall aim of this Position Paper of the ESC Working Group of Atherosclerosis and Vascular biology is to provide guidance for the next steps to be taken from pre-clinical studies on vascularization toward clinical application. To this end, the current state of knowledge in terms of therapeutic strategies for targeting vascularization in post-ischaemic disease is reviewed and discussed. A consensus statement is provided on how to optimize vascularization studies for the identification of suitable targets, the use of animal models of disease and the analysis of novel delivery methods.
dc.language.isoenglanti
dc.publisherOxford University Press (OUP)
dc.relation.ispartofseriesCARDIOVASCULAR RESEARCH
dc.relation.urihttp://dx.doi.org/10.1093/cvr/cvy184
dc.rightsAll rights reserved
dc.subjectpost-ischaemic angiogenesis
dc.subjectpre-clinical studies
dc.subjectgene and cell delivery
dc.subjectclinical trials
dc.titleFuture directions for therapeutic strategies in post-ischaemic vascularization: a position paper from European Society of Cardiology Working group on Atherosclerosis and Vascular Biology
dc.description.versionfinal draft
dc.contributor.departmentA.I. Virtanen -instituutti
uef.solecris.id55989202en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Authors
dc.relation.doi10.1093/cvr/cvy184
dc.description.reviewstatuspeerReviewed
dc.format.pagerange1411-1421
dc.relation.issn0008-6363
dc.relation.issue11
dc.relation.volume114
dc.rights.accesslevelopenAccess
dc.type.okmA2
uef.solecris.openaccessEi


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