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Approaches to improve the biocompatibility and systemic circulation of inorganic porous nanoparticles

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Article (2.438Mb)
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final draft
Date
2018
Author(s)
Tamarov, Konstantin
Näkki, Simo
Xu, Wujun
Lehto, Vesa-Pekka
Unique identifier
10.1039/c8tb00462e
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Self-archived article

Citation
Tamarov, Konstantin. Näkki, Simo. Xu, Wujun. Lehto, Vesa-Pekka. (2018). Approaches to improve the biocompatibility and systemic circulation of inorganic porous nanoparticles.  Journal of Materials Chemistry B, 6 (22) , 3632-3649. 10.1039/c8tb00462e.
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© Royal Society of Chemistry
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Abstract

The exploitation of various inorganic nanoparticles as drug carriers and therapeutics is becoming increasingly common. The first issue to be considered with regard to the nanomaterials being utilized in medicine centers on their safety. The functionality of nanocarriers in real-life environments explains the enthusiasm for their use. Several functionalities are typically added onto nanocarriers but the most crucial feature of those carriers intended to be administered intravenously is that they should possess a long residence time in the blood circulation. The present review focusses on the mesoporous nanoparticles due to their great promise in nanomedicine and concentrates on their coatings because it is the outmost layer which dictates their first interactions with the surroundings and often determines their biofate.

Subjects
inorganic nanovector   drug delivery   chemotherapy   photothermal therapy   photodynamic therapy   mesoporous material   functionalization   in vivo experiments   opsonization   biocompatibility   
URI
https://erepo.uef.fi/handle/123456789/6977
Link to the original item
http://dx.doi.org/10.1039/c8tb00462e
Publisher
Royal Society of Chemistry (RSC)
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  • Luonnontieteiden ja metsätieteiden tiedekunta [1109]
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