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dc.contributor.authorHaapasalo, Joonas
dc.contributor.authorNordfors, Kristiina
dc.contributor.authorGranberg, Kirsi J
dc.contributor.authorKivioja, Tomi
dc.contributor.authorNykter, Matti
dc.contributor.authorHaapasalo, Hannu
dc.contributor.authorSoini, Ylermi
dc.date.accessioned2018-10-05T11:32:48Z
dc.date.available2018-10-05T11:32:48Z
dc.date.issued2018
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/7026
dc.description.abstractNuclear factor erythroid 2-related factor 2 (NRF2), DJ1 and sulfiredoxin 1 (SRXN1) are transcription factors which protect cells from the oxidative damage caused by reactive oxygen species and, on the other hand, are associated with resistance to cancer treatments. The immunohistochemical expression of NRF2, DJ1 and SRNX1 was assessed in human grade II - IV astrocytic gliomas. Their association to clinicopathologic and essential molecular factors was evaluated. The RNA expression levels and genetic alterations were analyzed from publicly available datasets. All studied molecules were commonly expressed. The cytoplasmic NRF2 expression was higher in tumors with a higher malignancy grade, whereas the nuclear and cytoplasmic DJ1 expression was associated with a lower grade. The presence of the isocitrate dehyrdogenase 1 mutation (IDH1) was associated with an increasing cytoplasmic and nuclear expression of NRF2 and a nuclear DJ1 expression. When primary grade IV astrocytomas were compared to secondary glioblastomas, nuclear DJ1 was associated with secondary tumors. In grade II-IV tumors, the cytoplasmic NRF2 expression was associated with a poor prognosis, whereas nuclear NRF2 and both cytoplasmic and nuclear DJ1 were associated with a better patient prognosis. Recurrent homozygous deletions of DJ1 were observed, especially in the IDH wild-type samples. When only the glioblastomas were evaluated, nuclear NRF2 and SRNX1 predicted better survival. As a conclusion, NRF2, DJ1 and SNXR1 can be used as prognosticators in gliomas.
dc.language.isoenglanti
dc.relation.ispartofseriesHISTOLOGY AND HISTOPATHOLOGY
dc.relation.urihttp://dx.doi.org/10.14670/HH-11-973
dc.rightsCC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectNRF2
dc.subjectDJ1
dc.subjectSNXR1
dc.subjectglioma
dc.subjectprognosis
dc.titleNRF2, DJ1 and SNRX1 and their prognostic impact in astrocytic gliomas
dc.description.versionpublished version
dc.contributor.departmentSchool of Medicine / Clinical Medicine
uef.solecris.id52723881en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Universidad de Murcia
dc.relation.doi10.14670/HH-11-973
dc.description.reviewstatuspeerReviewed
dc.format.pagerange791-801
dc.relation.issn0213-3911
dc.relation.volume33
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessEi


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