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dc.contributor.authorLöfberg, Olli
dc.contributor.authorJulkunen, Petro
dc.contributor.authorKallioniemi, Elisa
dc.contributor.authorPääkkönen, Ari
dc.contributor.authorKarhu, Jari
dc.date.accessioned2018-10-05T11:52:36Z
dc.date.available2018-10-05T11:52:36Z
dc.date.issued2018
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/7027
dc.description.abstractLoud sounds have been demonstrated to increase motor cortex excitability when transcranial magnetic stimulation (TMS) is synchronized with auditory evoked N100 potential measured from electroencephalography (EEG). The N100 potential is generated by an afferent response to sound onset and feature analysis, and upon novel sound it is also related to the arousal reaction. The arousal reaction is known to originate from the ascending reticular activating system of the brain stem and to modulate neuronal activity throughout the central nervous system. In this study we investigated the difference in motor evoked potentials (MEPs) when deviant and novelty stimuli were randomly interspersed in a train of standard tones. Twelve healthy subjects participated in this study. Three types of sound stimuli were used: 1) standard stimuli (800 Hz), 2) deviant stimuli (560 Hz), and 3) novelty stimuli (12 different sounds). In each stimulus sequence 600 stimuli were given. Of these, 90 were deviant stimuli randomly placed between the standard stimuli. Each of 12 novel sounds was presented once in pseudorandomized order. TMS was randomly mixed with the sound stimuli so that it was either synchronized with the individual N100 or trailed the sound onset by 200 ms. All sounds elicited an increase in motor cortex excitability. The type of sound had no significant effect. We also demonstrated that TMS timed at 200-ms intervals caused a significant increment of MEPs. This contradicted our hypothesis that MEP amplitudes to TMS synchronized with N100 would be greater than those to TMS at 200 ms after a sound and remains unexplained.
dc.language.isoenglanti
dc.publisherAmerican Physiological Society
dc.relation.ispartofseriesJOURNAL OF NEUROPHYSIOLOGY
dc.relation.urihttp://dx.doi.org/10.1152/jn.00186.2017
dc.rightsAll rights reserved
dc.subjectarousal
dc.subjectauditory stimulation
dc.subjectevoked potentials
dc.subjectneurophysiology
dc.subjecttranscranial magnetic stimulation
dc.titleModulation of motor cortical excitability with auditory stimulation
dc.description.versionpublished version
dc.contributor.departmentSchool of Medicine / Biomedicine
dc.contributor.departmentDepartment of Applied Physics, activities
uef.solecris.id54453469en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© The American Physiological Society
dc.relation.doi10.1152/jn.00186.2017
dc.description.reviewstatuspeerReviewed
dc.format.pagerange920-925
dc.relation.issn0022-3077
dc.relation.issue3
dc.relation.volume120
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessEi


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